The role of dendritic cells in oral cancer

• Project/Area Number: 23592918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: KATOU Fuminori 浜松医科大学, 医学部, 教授 (60204492)
• Co-Investigator(Kenkyū-buntansha): WATANABE Yoshiko 浜松医科大学, 医学部, 助教 (10444358)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 口腔癌 / 樹状細胞

Outline of Final Research Achievements

Dendritic cells infiltrated to the tumor-stroma of oral squamous cell carcinoma. Some dendritic cells were indoleamin2,3-dioxygenase (IDO) positive. In the circumference of the IDO+ dendritic cells, there were a lot of T cells, and the dendritic cells and the Tcells formed a cluster.