| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We have already reported that the PDE1 signal affects the cell proliferation and motility in malignant melanoma cells. Therefore, we examined if the PDE5 inhibitor using for ED treatment, which also inhibits PDE1, is available as the therapeutic agent for malignant melanoma. Sildenafil inhibited cell motility of malignant melanoma MAA cells which expressed PDE1. Sildenafil was not effected for other oral malignant melanoma cells which did not express PDE1. As each oral malignant tumor cells showed the different PDE expression patterns and the effect of sildenafil varied by PDE expression pattern, PDE might be used for the personalized cancer therapy.
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