| Project/Area Number |
23592926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University (2013)
Kochi University (2011-2012) |
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Principal Investigator |
YAMADA Tomohiro 九州大学, 歯学研究科(研究院), 准教授 (60335619)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya 高知大学, 教育研究部医療学系, 教授 (00200824)
SASABE Eri 高知大学, 教育研究部医療学系, 助教 (40363288)
李 康広 高知大学, 医歯学系, 助教 (70587526)
大野 清二 高知大学, 医歯学系, 助教 (40624995)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口蓋裂 / 酸化ストレス / 口蓋骨 / 軟口蓋 / TCDD |
|---|
| Research Abstract |
To examine effect of the oxidative stress in the cleft palate pathogenesis, some oxidative stress inducers, i.e. TCDD, steroid, LPS, and D-galactosamine, were administered to pregnant mice. As a result, it was thought that palatogenesis was not received much effect by the oxidative stress only within the dam (liver in particular). Therefore TCDD administration mice were used as oxidative stress model. Because underexpression of osteogenesis-related protein and the myoblastic differentiation marker was observed, it was suggested that TCDD can induce cleft palate by dehiscence after the palate union with osteo-, and myogenesis suppression, in addition by the mechanism of palatal fusion inhibition.
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