| Project/Area Number |
23592930
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SUNAKAWA Hajime 琉球大学, 医学(系)研究科(研究院), 名誉教授 (30112452)
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| Co-Investigator(Kenkyū-buntansha) |
KINA Shinichiro 琉球大学, 大学院医学研究科, 助教 (40422422)
NIMURA Humikazu 琉球大学, 医学部附属病院, 助教 (50457678)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | HPV / 分子標的薬 / PDGFR / シスプラチン / Met |
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| Research Abstract |
For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here, we show that, PDGFR-mediated signaling plays a key role in HGF receptor (c-Met) upregulation, which in turn is thought to play an important role in chemotherapy resistance. PDGFR inhibition eliminates cisplatin dependent Met expression in HPV positive cancer cell lines. PDGFR inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering people from drug resistance in HPV positive cancer cells.
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