The elucidation of angiogenic and lymphangiogenic mechanism of the oral cancer by novel MIAgenefamily
| Project/Area Number |
23592935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
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| Co-Investigator(Renkei-kenkyūsha) |
KIRITA Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
YAMAMOTO Kazuhiko 奈良県立医科大学, 医学部, 准教授 (20243842)
BHAWAL Ujjal 日本大学, 歯学部, 助教 (50433339)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔癌 / MIA / MIA2 / TANGO / ＭＩＡ / ＭＩＡ２ / ＴＡＮＧＯ |
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| Research Abstract |
We revealed that melanoma inhibitory activity (MIA) is newly angiogenic and lymphangiogenic factor in oral squamous cell caarcinoma. More recently, MIA2 and TANGO genes were identified as novel MIA gene family. MIA2 and TANGO act as tumor suppressor gene in colorectal cancer, hepatocellular carcinoma, malignant melanoma, and so on. However,functional role of MIA gene family in malignancies are still unknownWe investigated more detailed functions of MIA2 and TANGO in oral squamous cell carcinoma. Our results suggested that MIA2 and TANGO have oncogenic function in oral cancer.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Cancer usurps skeletal muscle as an energy repository2013
Author(s)
Luo Y, Yoneda J, Ohmori H, Sasaki T, Shimbo K, Eto S, Kato Y, Miyano H, Kobayashi T, Sasahira T, Chihara Y, Kuniyasu H
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Journal Title
Cancer Res
Volume: 74(1)
Pages: 330-40
Related Report
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[Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingival inflammation2012
Author(s)
Ito Y, Bhawal UK, Sasahira T, Toyama T, Sato T, Matsuda D, Nishikiori H, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H
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Journal Title
Arch Oral Biol
Volume: 57(1)
Pages: 73-80
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[Journal Article] IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway2012
Author(s)
Bhawal UK, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, Sasahira T, Hamada N, Kuniyasu H, Arakawa H, Kato Y, Abiko Y
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Journal Title
J Cell Biochem
Volume: 113(10)
Pages: 3246-53
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[Journal Article] Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D12011
Author(s)
Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kijima H, Kuniyasu H, Abiko Y, Kato Y, Sato S
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Journal Title
J Pathol
Volume: 224(3)
Pages: 420-429
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[Journal Article]
Author(s)
Sasahira T, Kirita T, Yamamoto K, Ueda N, Kurihara M, Matsushima S, Bhawal UK, Bosserhoff AK, Kuniyasu H
Volume
(in press)
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