| Project/Area Number |
23592935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
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| Co-Investigator(Renkei-kenkyūsha) |
KIRITA Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
YAMAMOTO Kazuhiko 奈良県立医科大学, 医学部, 准教授 (20243842)
BHAWAL Ujjal 日本大学, 歯学部, 助教 (50433339)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔癌 / MIA / MIA2 / TANGO / ＭＩＡ / ＭＩＡ２ / ＴＡＮＧＯ |
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| Research Abstract |
We revealed that melanoma inhibitory activity (MIA) is newly angiogenic and lymphangiogenic factor in oral squamous cell caarcinoma. More recently, MIA2 and TANGO genes were identified as novel MIA gene family. MIA2 and TANGO act as tumor suppressor gene in colorectal cancer, hepatocellular carcinoma, malignant melanoma, and so on. However,functional role of MIA gene family in malignancies are still unknownWe investigated more detailed functions of MIA2 and TANGO in oral squamous cell carcinoma. Our results suggested that MIA2 and TANGO have oncogenic function in oral cancer.
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