| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We investigated the inhibitory effects of phenol related compounds; eugenol,bis-eugenol,honokiol、magnolol、p-cresol、p-cresol dimer、p-hydroxyanisole (pHA)、pHA dimer and tocopherols, and bioactive compounds; indol and melatonin on the redox-sensitive transcription factor activation stimulated with LPS or other stimulants in mammalian cells. Some of phenolic dimmers and melatonin inhibited a transcriptional activity of nuclear factor kappa B and also suppressed cyclooxygenase-2 expression. These observations suggested that inhibitory effects of these compounds on NF-κB activation and cox2 expression might be associated with their antioxidant activity. These antioxidant compounds may be applicable for preventing chronic inflammation and carcinogenesis.
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