Regulatory effects of redox-sensitive transcription factor activation by antioxidative phenol-related compounds.
| Project/Area Number |
23592939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔外科学一般 / 抗酸化性フェノール関連化合物 / 転写因子 |
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| Outline of Final Research Achievements |
We investigated the inhibitory effects of phenol related compounds; eugenol,bis-eugenol,honokiol、magnolol、p-cresol、p-cresol dimer、p-hydroxyanisole (pHA)、pHA dimer and tocopherols, and bioactive compounds; indol and melatonin on the redox-sensitive transcription factor activation stimulated with LPS or other stimulants in mammalian cells. Some of phenolic dimmers and melatonin inhibited a transcriptional activity of nuclear factor kappa B and also suppressed cyclooxygenase-2 expression. These observations suggested that inhibitory effects of these compounds on NF-κB activation and cox2 expression might be associated with their antioxidant activity. These antioxidant compounds may be applicable for preventing chronic inflammation and carcinogenesis.
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Report
(5 results)
Research Products
(7 results)
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[Journal Article] Comparative inhibitory effects of magnolol, honokiol, eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis.2012
Author(s)
Murakami,Y., Kawata,A., Seki,Y., Koh,T., Yuhara,K., Maruyama,T., Machino,M., Ito,S., Kadoma,Y., Fujisawa,S.
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Journal Title
In Vivo
Volume: 26
Pages: 941-950
Related Report
Peer Reviewed
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[Journal Article] Effect of melatonin on cyclooxygenase-2 expression and nucrear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis.2011
Author(s)
Murakami,Y., Yuhara,K., Takada,N., Arai,T., Tsuda,S., Takamatsu,S., Machino,M., Fujisawa,S.
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Journal Title
In vivo
Volume: 25
Pages: 641-648
Related Report
Peer Reviewed
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