Functional analysis of melanocortin receptor agonists in bone metabolism and the possibility of clinical application for osteonecrosis of the jaw

• Project/Area Number: 23592941
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Saitama Medical University
• Principal Investigator: SATO Tsuyoshi 埼玉医科大学, 医学部, 講師 (60406494)
• Co-Investigator(Kenkyū-buntansha): USUI Michihiko 九州歯科大学, 歯学部, 准教授 (10453630) ; 千田 大 独立行政法人国立国際医療研究センター, その他部局等, その他 (90312842)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Shu 東京医科歯科大学, 医学部, 教授 (30376727)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ACTH / 骨 / VEGF / MC2Rノックアウトマウス / VEGF-D / MC2R KO mice

Research Abstract

We investigated whether adrenocorticotropic hormone(ACTH) affects bone directly. using ACTH receptor knockout mice, bone mineral density was significantly upregulated. Osteoblast differentiation was inhibited and osteoclast differentiation was promoted by ACTH stimulation. In ACTH receptor knockout mice,VEGF-D expression was upregulated. Although ACTH is effective for vascularlization, there is the possibility that ACTH may inhibit bonew formation.

Research Products

• [Presentation] Hypothalamic-pituitary-adrenal axis is essential for the regulation of both bone and fat metabolism via melanocortin 2 receptor (2012)
  • Author(s): Sato T, Chida D, Iwata T, Usui M, Enoki Y, Matsumoto M, Xu R, Sunamura S, Ochi H, Fukuda T, Takeda S, Yoda T
  • Organizer: American Society for Bone and Mineral Research Annual Meeting, Minneapolis
  • Year and Date: 2012-10-13
• [Presentation] ストレスによる骨密度低下および肥満発症メカニズムの解明と創薬への展望 (2012)
  • Author(s): 佐藤毅
  • Organizer: 彩の国骨フォーラム研究会
  • Place of Presentation: 埼玉県
  • Year and Date: 2012-06-29
• [Presentation] 心因性ストレスは骨組織の減少および脂肪組織の増加を引き起こす (2012)
  • Author(s): 佐藤毅,榎木祐一郎,福島洋介,中本紀道,壁谷信,佐野良恵,中本文,坂田康彰,依田哲也
  • Organizer: 第66回日本口腔科学会
  • Place of Presentation: 広島市
  • Year and Date: 2012-05-18
• [Presentation] ストレスホルモンによる骨代謝への直接作用の解析 (2011)
  • Author(s): 佐藤毅,榎木祐一郎,中本紀道,福島洋介,坂田康彰,依田哲也
  • Organizer: 第45回口腔科学会関東地方部会
  • Place of Presentation: 東京都
  • Year and Date: 2011-11-19
• [Presentation] Hypothalamic-pituitary-adrenal axis is essential for the regulation of both bone and fat metabolism via melanocortin 2 receptor.
  • Author(s): Tsuyoshi Sato
  • Organizer: American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis(USA)