| Project/Area Number |
23592941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
SATO Tsuyoshi 埼玉医科大学, 医学部, 講師 (60406494)
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| Co-Investigator(Kenkyū-buntansha) |
USUI Michihiko 九州歯科大学, 歯学部, 准教授 (10453630)
千田 大 独立行政法人国立国際医療研究センター, その他部局等, その他 (90312842)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Shu 東京医科歯科大学, 医学部, 教授 (30376727)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ACTH / 骨 / VEGF / MC2Rノックアウトマウス / VEGF-D / MC2R KO mice |
|---|
| Research Abstract |
We investigated whether adrenocorticotropic hormone(ACTH) affects bone directly. using ACTH receptor knockout mice, bone mineral density was significantly upregulated. Osteoblast differentiation was inhibited and osteoclast differentiation was promoted by ACTH stimulation. In ACTH receptor knockout mice,VEGF-D expression was upregulated. Although ACTH is effective for vascularlization, there is the possibility that ACTH may inhibit bonew formation.
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