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A research for new treatment with parathyroid hormone and cyclooxygenase-2 for mandibular bone invasion by oral squamous cell carcinoma

Research Project

Project/Area Number 23592945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical University

Principal Investigator

SATOMI TAKAFUMI  東京医科大学, 医学部, 准教授 (70276921)

Co-Investigator(Kenkyū-buntansha) TSUZUKI Masako  東京医科大学, 医学部, 助教 (40385092)
ABUKAWA Harutsugi  東京医科大学, 医学部, 助教 (50453717)
WATANABE Masato  東京医科大学, 医学部, 講師 (40349460)
HASEGAWA On  東京医科大学, 医学部, 助教 (50424619)
MIZUGUCHI Junichirou  東京医科大学, 医学部, 教授 (20150188)
CHIKAZU Daichi  東京医科大学, 医学部, 教授 (30343122)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔癌 / 顎骨浸潤 / PTH / COX-2
Research Abstract

The aims of this study were to investigate the role of parathyroid hormone (PTH) up regulation by the cyclooxygenase-2 (COX-2) signaling pathway in bone invasion using oral squamous cell carcinoma (OSCC) mouse bone invasion model and to clarify new treatments of OSCC invasion into the jaw bone. We used 2 mouse SCC lines (NR-S1, SCC7) with different expressions of PTHrP and COX-2. C3H/HeN mice were inoculated with these cells in the masseter region to establish an animal model of mandibular invasion by OSCC. We measured tumor sizes of the mice, analyzed mandibular invasion by OSCC using micro-CT, then examined the TRAP staining and number of osteoclasts, and determined the mRNA expression of osteoclast-related cytokines by real-time PCR. We suggest that osteoclast-related cytokines play important roles in the bone invasion by OSCC cells.
Consequently, PTHrP inhibition by COX-2 signaling is expected to be a therapeutic target to prevent bone invasion by OSCC cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Solitary myofibroma of the mandible : an immunohistochemical and ultrastructural study with a review of the literature2014

    • Author(s)
      Satomi T, Kohno M, Enomoto A, Abukawa H, Fujikawa K, Koizumi T, Chikazu D, Matsubayashi J, Nagao T
    • Journal Title

      Med Mol Morphol

      Volume: (in press) Issue: 3 Pages: 176-183

    • DOI

      10.1007/s00795-013-0062-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exceptionally large solitary fibrous tumor arising from the cheek : an immunohistochemical and ultrastructural study with a review of the literature2014

    • Author(s)
      Satomi T, Hasegawa O, Abukawa H, Kohno M, Enomoto A, Chikazu D, Matsubayashi J, Nagao T
    • Journal Title

      Med Mol Morphol

      Volume: 47(2) Pages: 108-116

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma2013

    • Author(s)
      Kohno M, Watanabe M, Abukawa H, Hasegawa O, Satomi T, Chikazu D
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 71(10) Pages: 1694-1702

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical application of polyglycolic acid sheet after resection of tongue squamous cell carcinoma2013

    • Author(s)
      Fujikawa K, Abukawa H, Hasegawa O, Satomi T, Odan N, Matsuo A, Chikazu D
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: 25(3) Pages: 221-225

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chondrosarcoma of the maxilla extending to the pterygomandibular space : A case report and review of the literature2012

    • Author(s)
      Satomi T, Kaneko T, Abukawa, H Hasegawa O, Watanabe M, Matsubayashi J, Nagao T, Chiba H, Chikazu D
    • Journal Title

      J Maxillofac Oral Surg

      Volume: 14 Issue: S1 Pages: 133-137

    • DOI

      10.1007/s12663-012-0367-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced malignant fibrous histiocytoma of the maxilla2011

    • Author(s)
      Satomi T, Watanabe M, Kaneko T, Matsubayashi J, Nagao T, Chiba H
    • Journal Title

      Odontology

      Volume: 99 Pages: 203-208

    • NAID

      10029548832

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 日常臨床における口腔がんへの対処のしかた2012

    • Author(s)
      里見貴史
    • Organizer
      埼玉県日本歯科大学校友会「埼玉富士見クラブ」主催学術講演会
    • Place of Presentation
      埼玉県大宮歯科医師会会館,大宮
    • Year and Date
      2012-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 知っていますか?口の中のがんのこと〜口腔がんの予防と早期発見2012

    • Author(s)
      里見貴史
    • Organizer
      第65回東京医科大学病院市民公開講座
    • Place of Presentation
      東京医科大学病院6F臨床講堂,東京
    • Year and Date
      2012-04-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるCyclooxygenase2(COX2)発現とリンパ節転移について2012

    • Author(s)
      河野通秀、渡辺正人、長谷川温、虻川東嗣、里見貴史、近津大地
    • Place of Presentation
      島根県民会館、松江
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of metabolic enzymes associated with fluoropyrimidine sensitivity in oral squamous cell carcinoma2011

    • Author(s)
      Masato Watanabe, Michihide Kohno, On Hasegawa, Harutsugi Abukawa, Takafumi Satomi, Tadayosi Kaneko, Akira Matsuo, Daichi Chikazu
    • Organizer
      IAOO 3rd World Congress
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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