| Project/Area Number |
23592946
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
HASEGAWA ON 東京医科大学, 医学部, 助教 (50424619)
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| Co-Investigator(Kenkyū-buntansha) |
CHIKAZU Daichi 東京医科大学, 医学部, 教授 (30343122)
ABUKAWA Harutsugi 東京医科大学, 医学部, 助教 (50453717)
MATSUO Akira 東京医科大学, 医学部, 准教授 (70229417)
NAKAI Takayuki 東京医科大学, 医学部, 助教 (70349471)
SATOMI Takafumi 東京医科大学, 医学部, 准教授 (70276921)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ハイドロキシアパタイト骨補填材 / COX-2ノックアウトマウス / cox-2ノックアウトマウス / COX-２ノックアウトマウス |
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| Outline of Final Research Achievements |
The aim of this study was to examine the role of cyclooxygenase(cox)-2 on bone response after the placement of porous hydroxyapatite synthetic bone, Radiological & Histopathological. Both radiological & histopathological study showed no significant difference between wildmice and knockout mice. Although new bone formation on porous hydroxyapatite was visible, there is no woven bone formation was observed in cox-2 knockout mice. Possibility that cox-2 involved in bone reaction around the porous hydroxyapatite synthetic bone has been highly suggested.
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