Role of cystatin in stimulation of saliva flow and protection of oral mucosa

• Project/Area Number: 23592948
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University
• Principal Investigator: NAKAGAWA Yoichi 鶴見大学, 歯学部, 講師 (90148057)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: シェーグレン症候群 / シスタチン / 唾液分泌 / 生体防御

Research Abstract

The cystatins are a family of cysteine protease inhibitors. Cysteine protease inhibitors are assumed to have important roles in apoptosis. Salivary cystatin decreased in Sjogren's syndrome patients, particularly cystatin S. In the labial salivary glands, intense staining of the cystatin was observed in the normal control group, but there were few positive examples in Sjogren's syndrome patients, and the staining was extremely low. These results suggest that the cystatin participates in the regulation of onset of Sjogren's syndrome.