Elucidation of the cell differentiation molecular regulation mechanism in proliferative lesions of the oral cavity using bone marrow stem cell transplantation model
| Project/Area Number |
23592951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Keisuke 松本歯科大学, 歯学部, 准教授 (10325095)
TOMIDA Mihoko 松本歯科大学, 歯学部, 准教授 (00366329)
TSUJIGIWA Hidetugu 岡山大学, 医歯()学総合研究科, 准教授 (70335628)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨髄幹細胞 / 腫瘍 / 増殖性疾患 / 組織修復 / 再生 / 増殖性病変 / 歯原性腫瘍 / 分子調節 / 組織誘導 |
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| Research Abstract |
We investigated the dynamics of bone marrow stem cells in tissue repair using GFP bone marrow transplantation mouse. We clarified following results.
1) The expression of Runx2, Msx2, ALP, Neuroendocrine-related factors and HSPs were enhanced in the periodontal ligament under injurious stimuli. 2) These factors have important roles in tissue repair and homeostasis of periodontal tissue. 3) Bone marrow stem cells engraft in active growth sites. 6) Scientific basis that allows for control of proliferative disease and promoting tissue repair using bone marrow stem cells.
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Report
(4 results)
Research Products
(86 results)
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[Presentation] Focal osseous dysplasiaの1例2013
Author(s)
下地茂弘,高田匡基,丸川和也,伊藤香那,嶋田勝光,落合隆永,中野敬介,内田啓一,長谷川博雅,田口明,篠原淳,各務秀明
Organizer
日本口腔科学会中部地方部会(第56回)
Place of Presentation
石川県教育会館,金沢市
Year and Date
2013-09-28
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[Presentation] 外傷ストレスを負荷した歯周組織変化2013
Author(s)
岡藤範正,中野敬介,魚住智子,山木貴子,安東信行,安東史子,中村曲正,横井由紀子,大須賀直人,西川康弘
Organizer
日本外傷歯学会総会・学術大会(第13回)
Place of Presentation
所沢市民文化センターミューズ,所沢市
Year and Date
2013-07-20
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[Presentation] 下顎臼歯根尖部病変2013
Author(s)
落合隆永,嶋田勝光,中野敬介,長谷川博雅
Organizer
骨軟部腫瘍研究会(第49回)
Place of Presentation
日本口腔科学会中部地方部会(第56回)
Year and Date
2013-06-05
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[Presentation] 下顎臼歯根尖部病変
Author(s)
落合隆永，嶋田勝光，中野敬介，長谷川博雅
Organizer
骨軟部腫瘍研究会（第49回）
Place of Presentation
大分大学, 大分市
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[Book] Pathological Basis of Root Canal Restoration -Using Calcium Hydroxide Paste-, IDP Publishing Inc2012
Author(s)
Antoh M, Fuchino T, Fujii H, Hasegawa H, Kawakami T, Machida Y, Mizutani T, NakamuraC, Nakano K, Ochiai T, Sato M, Shibuya T, Takei N, Teramoto S, Tomida M, Yumii T
Publisher
Kawakami T ed
Related Report
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[Book] Pathological Basis of Root Canal Restoration -Using Calcium Hydroxide Paste-2012
Author(s)
Antoh M, Fuchino T, Fujii H, Hasegawa H, Kawakami T, Machida Y, Mizutani T, Nakamura C, Nakano K, Ochiai T, Sato M, Shibuya T, Takei N, Teramoto S, Tomida M and Yumii T
Total Pages
232
Publisher
IDP Publishing Inc.
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