Study on mechanism of vital staining with iodine solution and disorder of glycogen metabolism in oral squamous cell carcinoma

• Project/Area Number: 23592959
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Shinshu University
• Principal Investigator: KURITA HIROSHI 信州大学, 医学部, 教授 (10273103)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ヨード染色 / グリコーゲン / 口腔扁平上皮癌 / 生体染色 / 糖代謝 / ルゴール染色 / 臨床腫瘍学 / 口腔粘膜

Research Abstract

Vital staining with iodine solution has been used in diagnosis and treatment of oral squamous cell carcinoma (OSCC). The results of this study suggested that Iodine infiltrated and reacted with intra-cell glycogen (full- and surrounded- type) mainly in the upper superficial layer of the non-keratinized epithelium. And it was also suggested that OSCC cells showed significant increase of glucose uptake and accelerated glycogen breakdown.

Research Products

• [Journal Article] Iodine penetration and glycogen distribution in vital staining of oral mucosa with iodine solution (2014)
  • Author(s): Xiao T, Kurita H, Li X, Qi F, Shimane T, Aizawa H, Uehara S
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 117 Issue: 6 Pages: 754-759
  • DOI: 10.1016/j.oooo.2014.02.008
  • Peer Reviewed
• [Journal Article] Iodine penetration and glycogen distribution in vital staining of oral mucosa with iodine solution (2014)
  • Author(s): Tiepeng Xiao, Hiroshi Kurita, Xiangjun Li, Fangfang Qi DDS , Tetsu Shimane, Hitoshi Aizawa, Shinobu Uehara
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Volume: accepted
  • Peer Reviewed
• [Journal Article] Vital staining with iodine solution in oral cancer: iodine infiltration, cell proliferation, and glucose transporter 1 (2013)
  • Author(s): Tiepeng Xiao, Hiroshi Kurita, Tetsu Shimane, Yoshitaka Nakanishi, Takeshi Koike
  • Journal Title: Int J Clin Oncol Volume: accepted Issue: 5 Pages: 792-800
  • DOI: 10.1007/s10147-012-0450-4
  • Peer Reviewed
• [Presentation] Vital staining with iodine solution and glycogen metabolism in oral squamous cell carcinoma (2013)
  • Author(s): Aizawa H, Xiao T, Kobayashi H, Shimane T, Kurita H
  • Organizer: 21st International conference on oral and maxillofacial surgery
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2013-10-21
• [Presentation] 口腔扁平上皮癌におけるグリコーゲンに関する検討 (2013)
  • Author(s): 相澤仁志,肖鉄鵬,小林啓一,小池剛史,嶋根哲,斉芳芳,栗田浩
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-14
• [Presentation] Vital staining with iodine solution in OSCC:Iodine infiltration, cell proliferation and GLUT1 (2012)
  • Author(s): Xiao T, Kurita H, Shimane T, Nakanishi Y, Koike T
  • Organizer: 10th Asian Congress of Oral and Maxillofaicial Surgeons
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2012-11-18
• [Presentation] 口腔扁平上皮癌におけるヨード生体染色機序の解明2.上皮に染みこむ部位とグリコーゲン分布の関連について (2012)
  • Author(s): 肖鉄鵬,栗田浩,西牧史洋,嶋根哲,飯島響,鎌田孝広,小池剛史
  • Organizer: 第30回日本口腔腫瘍学会総会
  • Place of Presentation: さいたま市
  • Year and Date: 2012-01-26
• [Presentation] 口腔扁平上皮癌におけるヨード生体染色機序の解明 ２．上皮に染みこむ部位とグリコーゲン分布の関連について (2012)
  • Author(s): 肖 鉄鵬、栗田 浩、ほか
  • Organizer: 日本口腔腫瘍学会総会
  • Place of Presentation: さいたま市
• [Presentation] 口腔扁平上皮癌におけるヨード生体染色機序の解明 (2011)
  • Author(s): 肖鉄鵬,栗田浩,李向軍,嶋根哲,飯島響,鎌田孝広,小池剛史,小林啓一
  • Organizer: 第49回日本癌治療学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-27
• [Presentation] 口腔扁平上皮癌におけるヨード生体染色機序の解明 (2011)
  • Author(s): 肖 鉄鵬、栗田 浩、ほか
  • Organizer: 日本癌治療学会総会
  • Place of Presentation: 名古屋市
• [Presentation] 口腔扁平上皮癌におけるグリコーゲンに関する検討
  • Author(s): 相澤仁志、肖 鉄鵬、小林啓一、小池剛史、嶋根 哲、斉 芳芳、栗田 浩
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Vital staining with iodine solution in OSCC: Iodine infiltration, cell proliferation and GLUT1
  • Author(s): Xiao T, Kurita H, Shimane T, Nakanishi Y, Koike T
  • Organizer: 10th Asian Congress of Oral and Maxillofaicial Surgeons
  • Place of Presentation: Bali, Indonesia