Study on mechanism of vital staining with iodine solution and disorder of glycogen metabolism in oral squamous cell carcinoma
| Project/Area Number |
23592959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ヨード染色 / グリコーゲン / 口腔扁平上皮癌 / 生体染色 / 糖代謝 / ルゴール染色 / 臨床腫瘍学 / 口腔粘膜 |
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| Research Abstract |
Vital staining with iodine solution has been used in diagnosis and treatment of oral squamous cell carcinoma (OSCC). The results of this study suggested that Iodine infiltrated and reacted with intra-cell glycogen (full- and surrounded- type) mainly in the upper superficial layer of the non-keratinized epithelium. And it was also suggested that OSCC cells showed significant increase of glucose uptake and accelerated glycogen breakdown.
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Report
(4 results)
Research Products
(12 results)
