| Project/Area Number |
23592963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
SHIGEISHI HIDEO 広島大学, 医歯薬保健学研究院, 助教 (90397943)
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| Co-Investigator(Kenkyū-buntansha) |
KAMATA Nobuyuki 広島大学, 医歯薬保健学研究院, 教授 (70242211)
HIGASHIKAWA Koichiro 広島大学, 病院, 講師 (80363084)
ONO Shigehiro 広島大学, 医歯薬保健学研究院, 助教 (70379882)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | RHAMM / 唾液腺癌 / 口腔扁平上皮癌 / 癌幹細胞 / 口腔癌 |
|---|
| Research Abstract |
In head and neck cancers, elevated expression of RHAMM was associated with high proliferation of cancer cells. In addition, we demonstrated that there were two biologically different cancer stem cell (CSC) phenotypes of salivary gland carcinoma and oral squamous cell carcinoma, one of which is CD44high/ epithelial specific antigen (ESA) low cells, which have mesenchymal characteristics and are migratory, while the other phenotype is CD44high/ESAhigh cells, which have epithelial properties and high proliferative capacity, and harbor increased RHAMM expression. Since RHAMM is required for holoclone forming of CD44high/ESAhigh cells, it appears that it has a role in the self-renewal ability of head and neck CSC.
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