• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Overexpression of the atypical protein kinase C rambda/iota in oral squamous cell carcinoma is associated with degrees of malignancy

Research Project

Project/Area Number 23592972
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionYokohama City University

Principal Investigator

KOIZUMI Toshiyuki  横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (80323575)

Co-Investigator(Kenkyū-buntansha) MITSUDOH Kenji  横浜市立大学, 医学部, 准教授 (70303641)
KIOI Mitomu  横浜市立大学, 医学部, 准教授 (30545059)
NAGASHIMA Youji  横浜市立大学, 医学研究科, 准教授 (10217995)
AKIMOTO Kazunori  東京理科大学, 薬学部, 准教授 (70285104)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔扁平上皮癌 / aPKCλ/ι / Cancer stem cell / IL-6 / 口腔がん
Research Abstract

Atypical protein kinase C lambda/iota (aPKC lambda/iota) is a cell polarity-regulating protein and is localized in the tight junction or apical membrane in the epithelial cell. Previous studies suggested that aPKC lambda/iota over-expression and abnormal localization were involved in tumor progression in some cancers. We investigated the correlation between the aPKC lambda/iota expression pattern and the clinicopathological parameters in oral squamous cell carcinoma (OSCC) cases immunohistochemically, and evaluated the utility of aPKC lambda/iota expression pattern as a biomarker for the degree of malignancy.
As a result, we found immunostaining for aPKC lambda/iota was more intense in poorly differentiated OSCC, compared with moderately- and well- differentiated cases. In addition, cases of younger ages showed intense immunostaining for aPKC lambda/iota than in older. These results suggest that aPKC lambda/iota overexpression might be useful to predict the clinical outcomes of OSCC.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Chemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer2013

    • Author(s)
      小泉敏之、光藤健司、小栗千里、岩井俊憲、光永幸代、飯坂友宏、來生知、廣田誠、近津大地、藤内祝
    • Journal Title

      Toukeibu Gan

      Volume: 39 Issue: 4 Pages: 443-448

    • DOI

      10.5981/jjhnc.39.443

    • NAID

      130004510193

    • ISSN
      1349-5747, 1881-8382
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 進行口腔癌に対する逆行性超選択的動注化学放射線療法 上顎歯肉扁平上皮癌(T3、4)に対する治療効果の検討2013

    • Author(s)
      小泉 敏之, 光藤 健司, 小栗 千里, 岩井 俊憲, 光永 幸代, 飯坂 友宏, 來生 知, 廣田 誠, 近津 大地, 藤内 祝
    • Journal Title

      頭頸部癌

      Volume: 39 Pages: 443-448

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔癌の頸部リンパ節転移に対するハイパーサーミアを併用した術前動注化学療法の治療効果2013

    • Author(s)
      小泉敏之
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2013-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 進行口腔癌に対する逆行性超選択的動注化学放射線療法-上顎歯肉癌(T3,4)に対する治療効果の検討2012

    • Author(s)
      小泉敏之
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      松江
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるaPKCλ/ι過剰発現の臨床病理学的意義2011

    • Author(s)
      馬場隼一,秋本和憲,長嶋洋治,石黒 斉,來生 知,光藤健司,稲山嘉明,青木一郎,大野茂男,藤内 祝
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 口腔扁平上皮癌におけるaPKC λ/ι過剰発現の臨床病理学的意義2011

    • Author(s)
      馬場隼一,足立 誠,岩井俊憲,小栗千里,小泉敏之,來生 知,廣田 誠,光藤健司,藤内 祝
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      グランキューブ大阪(大阪府)
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi