Experimental study on vascularized bone regeneration in vivo using artificial bone supplementation material
| Project/Area Number |
23592973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Miyazaki (2013-2015)
Fukuoka Dental College (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 顎骨再建 / 血管柄付骨 / 骨再生 / 血管柄付骨組織 / 人工骨 / 生体内 / 血管柄付再生骨 |
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| Outline of Final Research Achievements |
This study is a bioresorbable ceramic b-TCP block embedded in the latissimus dorsi muscle film portion of the beagle dog, which was an attempt to create a blood vessel pattern with bone tissue to a scaffold. Was a self-blood implanted beneath group and the control group, along with the b-TCP. The chamber after six months were collected and histologically search. In the control group, the formation of bone tissue in all was not observed. On the other hand, bone formation was observed in the b-TCP + autologous blood group. Is in and around the bone marrow of the bone tissue is scattered microvascular, these microvessels was confirmed by immunohistochemistry. Our results were successfully created in the inflammatory response and foreign body reaction without vascularized with bone tissue. However formation of bone tissue is small, it was considered necessary approach for obtaining better reproduction bone.
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Report
(6 results)
Research Products
(3 results)
