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Study of pharmacological action and the adverse effect of the local anesthetic from a new viewpoint

Research Project

Project/Area Number 23592977
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

FUKUSHIMA KAZUAKI  北海道大学, -, 名誉教授 (00002361)

Co-Investigator(Kenkyū-buntansha) SUZUKI Kuniaki  北海道大学, 大学院歯学研究科, 教授 (40133748)
HIRAOKI Toshifumi  北海道大学, 大学院歯学研究科, 特任教授 (10125346)
FUJISAWA Toshiaki  北海道大学, 大学院歯学研究科, 教授 (30190028)
SHIBUYA Makiko  北海道大学, 大学院歯学研究科, 助教 (30399951)
KIMURA Yukifumi  北海道大学, 大学病院, 助教 (00292037)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords局所麻酔薬 / 麻酔作用 / 有害作用 / Ca-ATPase / Mg-ATPase / ラット脳 / Na,K-ATPase / アルカリ性ホスファターゼ / リン脂質 / リポソーム / 骨芽細胞
Research Abstract

Local anesthetics are supposed to produce anesthetic action by inhibiting a neuronal sodium channel, but this inhibition cannot explain all the effects of the local anesthetic and various kinds of adverse effect. Several kinds of Ca - and Mg-ATPase were present in rat brain, but in this study, the local anesthetic inhibited Ca - Mg-ATPase activity that work in alkaline pH. Also, local anesthetic with strong anesthetic effects strongly inhibited Na,K-ATPase activity. These ATPases may be associated with effects of the local anesthetic.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2014 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results)

  • [Journal Article] ラット脳各種ATPase活性に対する静脈麻酔薬の作用2014

    • Author(s)
      宮本健志、出山義昭、吉村善隆、鈴木邦明、藤澤俊明
    • Volume
      (in press)
    • NAID

      120006352238

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 局所麻酔薬アレルギーが疑われ北海道大学病院歯科麻酔科外来を受診した症例の検討2014

    • Author(s)
      岩本理恵、北条敬之、渋谷真希子、木村幸文、亀倉更人、藤澤俊明
    • Journal Title

      北海道歯誌

      Volume: 34 Pages: 114-119

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 局所麻酔薬アレルギーが疑われ北海道大学病院歯科麻酔科外来を受診した症例の検討2014

    • Author(s)
      岩本理恵、北条敬之、渋谷真希子、木村幸文、亀倉更人、藤澤俊明
    • Journal Title

      北海道歯学雑誌

      Volume: 34 Pages: 114-118

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット脳各種ATPase活性に対する静脈麻酔薬の作用2014

    • Author(s)
      宮本健志、出山義昭、吉村善隆、鈴木邦明、藤澤俊明
    • Journal Title

      北海道歯学雑誌

      Volume: 35

    • NAID

      120006352238

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトアルカリ性ホスファターゼの基質選択性と阻害剤に対する感受性の相違2014

    • Author(s)
      更田恵理子、出山義昭、吉村善隆、鈴木邦明、山崎裕
    • Journal Title

      北海道歯学雑誌

      Volume: 35

    • NAID

      120006352240

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨芽細胞の増殖、分化と石灰化におけるNa,K-ATPaseの役割2014

    • Author(s)
      山田淳一、出山義昭、吉村善隆、鈴木邦明、八若保孝
    • Journal Title

      北海道歯学雑誌

      Volume: 35

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na,K-ATPase活性のフッ素による阻害2014

    • Author(s)
      沖野雄一郎、出山義昭、吉村善隆、鈴木邦明、本多丘人
    • Journal Title

      北海道歯学雑誌

      Volume: 35

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット脳カルシウムATPase活性の静脈麻酔薬による抑制2012

    • Author(s)
      田仲宏光,出山義昭,吉村善隆,鈴木邦明,福島和昭
    • Journal Title

      北海道歯誌

      Volume: 32 Pages: 222-229

    • NAID

      10030576495

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism for propofol inhibition of Na,K-ATPase activity in rat brain(英語論文)2012

    • Author(s)
      Y. Hase, Y. Deyama, Y. Yoshimura, K. Suzuki, K. Fukushima
    • Journal Title

      北海道歯誌

      Volume: 32 Pages: 147-155

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of general anesthetics on ESR spectra of spin labels in phosphatidylcholine vesicles containing purified Na,K-ATPase or microsomal protein2012

    • Author(s)
      M. Shibuya, T. Hiraoki, K. Kimura, K. Suzuki, K. Fukushima
    • Journal Title

      Applied Surface Science

      Volume: 262 Pages: 102-106

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of general anesthetics on ESR spectra of spin labels in phosphatidylcholine vesicles containing purified Na,K-ATPase or microsomal protein.2012

    • Author(s)
      M. Shibuya, T. Hiraoki, K. Kimura, K. Suzuki, K. Fukushima
    • Journal Title

      Applied Surface Science

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism for propofol inhibition of Na,K-ATPase activity in rat brain.2012

    • Author(s)
      Y. Hase, Y. Deyama, Y. Yoshimura, K. Suzuki, K. Fukushima
    • Journal Title

      Hokkaido J. Dent. Sci.

      Volume: 32 Pages: 147-155

    • NAID

      10030576277

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] The effects of general anesthetics on ESR spectra of spin labels in liposome containing with membrane proteins2012

    • Author(s)
      M. Shibuya, K. Suzuki, K. Kimura, T. Hiraoki, K. Fukushima
    • Organizer
      13th International Dental Congress on Anesthesia, Sedationand Pain Control (IFDAS 2012)
    • Place of Presentation
      Kohala Coast, Big Island of Hawaii, USA
    • Year and Date
      2012-03-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanism for propofol inhibition of Na^+,K^+-ATPase activity in rat brain2011

    • Author(s)
      Y. Hase, K. Suzuki, T. Fujisawa, K. Fukushima
    • Organizer
      The 4^<th> Annual Meeting of the Federation of Asian Dental Anesthesiology Society
    • Place of Presentation
      Kobe International Conference Center (Kobe)
    • Year and Date
      2011-10-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 静脈麻酔薬によるラット脳Mg-及びCa,Mg-ATPase活性の抑制2011

    • Author(s)
      田仲宏光、出山義昭、吉村善隆、福島和昭、鈴木邦明
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2011-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 静脈麻酔薬プロポフォールによるラット脳Na,K-ATPase活性阻害2011

    • Author(s)
      長谷由理、出山義昭、吉村善隆、福島和昭、鈴木邦明
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of general anesthetics on ESR spectra of spin labels in phosphatidylcholine vesicles2011

    • Author(s)
      M. Shibuya, T. Hiraoki, K. Kimura, K. Fukushima, K. Suzuki
    • Organizer
      3^<rd> International Symposium on Surface and Interface of Biomedicine
    • Place of Presentation
      Hokkaido University (Sapporo)
    • Year and Date
      2011-07-11
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of general anesthetics on ESR spectra of spin labels in phosphatidylcholine vesicles.2011

    • Author(s)
      M. Shibuya, T. Hiraoki, K. Kimura, K. Fukushima, K. Suzuki
    • Organizer
      3rd International Symposium on Surface and Interface of Biomedicine
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mechanism for propofol inhibition of Na+,K+-ATPase activity in rat brain2011

    • Author(s)
      Y. Hase, K. Suzuki, T. Fujisawa, K. Fukushima
    • Organizer
      The 4th Annual Meeting of the Federation of Asian Dental Anesthesiology Society,
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 各種阻害剤のヒトアルカリ性ホスファターゼ・アイソザイムに対する作用の相違

    • Author(s)
      鈴木邦明、出山義昭、吉村善隆
    • Organizer
      第33回日本歯科薬物療法学会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] エストロゲンの骨芽細胞様MC3T3-E1細胞の各種ATPaseに対する作用

    • Author(s)
      孔 礼群、鈴木邦明、出山義昭、工藤智也、吉村善隆
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Na,K-ATPase活性及びそのリン酸化反応中間体量に対するフッ素の作用

    • Author(s)
      沖野雄一郎、出山義昭、吉村善隆、鈴木邦明
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨芽細胞におけるNa,K-ATPaseの機能

    • Author(s)
      山田淳一、出山義昭、吉村善隆、鈴木邦明、八若保孝
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Na,K-ATPase活性及びそのリン酸化反応中間体に対するベリリウムとフッ素の作用

    • Author(s)
      沖野雄一郎、出山 義昭、 吉村 善隆、鈴木 邦明
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] フッ素とベリリウムによるNa,K-ATPase 活性阻害の相違

    • Author(s)
      沖野雄一郎、出山 義昭、 吉村 善隆、鈴木 邦明
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡市)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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