Study of pharmacological action and the adverse effect of the local anesthetic from a new viewpoint
| Project/Area Number |
23592977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kuniaki 北海道大学, 大学院歯学研究科, 教授 (40133748)
HIRAOKI Toshifumi 北海道大学, 大学院歯学研究科, 特任教授 (10125346)
FUJISAWA Toshiaki 北海道大学, 大学院歯学研究科, 教授 (30190028)
SHIBUYA Makiko 北海道大学, 大学院歯学研究科, 助教 (30399951)
KIMURA Yukifumi 北海道大学, 大学病院, 助教 (00292037)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 局所麻酔薬 / 麻酔作用 / 有害作用 / Ca-ATPase / Mg-ATPase / ラット脳 / Na,K-ATPase / アルカリ性ホスファターゼ / リン脂質 / リポソーム / 骨芽細胞 |
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| Research Abstract |
Local anesthetics are supposed to produce anesthetic action by inhibiting a neuronal sodium channel, but this inhibition cannot explain all the effects of the local anesthetic and various kinds of adverse effect. Several kinds of Ca - and Mg-ATPase were present in rat brain, but in this study, the local anesthetic inhibited Ca - Mg-ATPase activity that work in alkaline pH. Also, local anesthetic with strong anesthetic effects strongly inhibited Na,K-ATPase activity. These ATPases may be associated with effects of the local anesthetic.
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Report
(4 results)
Research Products
(25 results)
