| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
<Purpose>The objective of this study was to evaluate the effectiveness of PRP in inducing the healing of tooth extraction-related sockets for better prognosis of tooth transplantation. <Materials and Methods> All molars of rats were extracted, and bone defects were made. Blood was drawn from other rats, and PRP was prepared.The specimens werestained with hematoxylin and eosin. The sections were also studied immuno-histochemically.<Results and Conclusions> PRP treatment induced the formation of a rich fibrin network and early inflammatory reactions in the experimental group, which may have led to the development of thick, vessel-rich granulation tissue. These results suggest that the growth factors secreted from granulation tissue may have stimulated wound healing in the experimental group. Consequently, the application of PRP may induce wound healing in tooth extraction-related bone defects.
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