| Project/Area Number |
23592988
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NIWA Hitoshi 大阪大学, 歯学研究科(研究院), 教授 (30218250)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMURA Mitsutaka 大阪大学, 大学院歯学研究科, 准教授 (90244954)
MASAWAKI Aya 大阪大学, 歯学部附属病院, 医員 (50609659)
MAEGAWA Hiroharu 大阪大学, 歯学部附属病院, 医員 (10711012)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | パーキンソン病 / 口腔顔面痛 / 疼痛関連行動 / ホルマリンテスト / 痛覚 / c-Fos / ラット / 三叉神経 / c－Fos / ﾎﾙﾏﾘﾝテスト |
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| Research Abstract |
We investigated the modulation of the nociceptive stimuli from the orofacial region in Parkinson's disease (PD) model rats, which were produced by the unilateral or bilateral injection of 6-OHDA into the medial forebrain bundle. Behavioral responses to formalin injection into the upper lip and the expression of c-Fos and pERK in trigeminal spinal subnucleus caudalis (Vc) were explored.
Unilateral PD rats showed increased nociceptive responses when formalin was injected ipsilaterally to the lesion. This hyperalgesic response was associated with increased c-Fos expression in Vc. When formalin was injected into contralateral side to 6-OHDA lesion, behavioral responses were reduced in 6-OHDA rats. However, the expression of pERK in Vc remained unchanged. Although the hyperalgesic response was not observed in bilateral PD rats, c-Fos expression in Vc increased.
These results suggest that 6-OHDA resion causes hyperalgesic response to nociceptive stimulation from the orofacial region.
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