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Behavioral responses and Fos activation following orofacial formalin injection in a rodent model of Parkinson's disease

Research Project

Project/Area Number 23592988
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

NIWA Hitoshi  大阪大学, 歯学研究科(研究院), 教授 (30218250)

Co-Investigator(Kenkyū-buntansha) SUGIMURA Mitsutaka  大阪大学, 大学院歯学研究科, 准教授 (90244954)
MASAWAKI Aya  大阪大学, 歯学部附属病院, 医員 (50609659)
MAEGAWA Hiroharu  大阪大学, 歯学部附属病院, 医員 (10711012)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsパーキンソン病 / 口腔顔面痛 / 疼痛関連行動 / ホルマリンテスト / 痛覚 / c-Fos / ラット / 三叉神経 / c-Fos / ホルマリンテスト
Research Abstract

We investigated the modulation of the nociceptive stimuli from the orofacial region in Parkinson's disease (PD) model rats, which were produced by the unilateral or bilateral injection of 6-OHDA into the medial forebrain bundle. Behavioral responses to formalin injection into the upper lip and the expression of c-Fos and pERK in trigeminal spinal subnucleus caudalis (Vc) were explored.
Unilateral PD rats showed increased nociceptive responses when formalin was injected ipsilaterally to the lesion. This hyperalgesic response was associated with increased c-Fos expression in Vc. When formalin was injected into contralateral side to 6-OHDA lesion, behavioral responses were reduced in 6-OHDA rats. However, the expression of pERK in Vc remained unchanged. Although the hyperalgesic response was not observed in bilateral PD rats, c-Fos expression in Vc increased.
These results suggest that 6-OHDA resion causes hyperalgesic response to nociceptive stimulation from the orofacial region.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] パーキンソン病モデルラットにおける顔面領域の疼痛刺激に対する行動学的反応とC-Fos発現2011

    • Author(s)
      前川博治、朴 會士、正脇 綾、遠山 緑、丹羽 均
    • Organizer
      第39回日本歯科麻酔学会総会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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