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The elucidation of role of motor neurons or pain pathways of the spinal cord in analgesia, muscle reluxation, and immobility as general anesthetic factors

Research Project

Project/Area Number 23592992
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

IRIFUNE MASAHIRO  広島大学, 医歯薬保健学研究院(歯), 教授 (10176521)

Co-Investigator(Kenkyū-buntansha) MORITA Katsuya  広島文化学園大学, 看護学部, 教授 (10116684)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords全身麻酔要素 / 正向反射 / 鎮痛 / 不動化 / MK-801 / ハロペリドール / デクスメデトミジン / モルヒネ / 正向反射の消失 / サブスタンスP / 意識消失 / 全身麻酔作用 / 麻酔要素 / 筋弛緩 / GABA / グリシン
Research Abstract

The role of substance P (SP) of the spinal cord in immobility as one of the general anesthetic factors was studied. Dexmedetomidine and morphine inhibit SP release from primary afferent neurons in the spinal cord. The selective N-methyl-D-aspartate (NMDA) channel blocker MK-801 is known to induce no loss of the righting reflex (LORR) and to stimulate catecholaminergic neurons in rodents, playing a crucial role in arousal. MK-801 in combination with a small dose of the dopamine (DA) receptor antagonist haloperidol dose-dependently produced LORR, but not immobility. Dexmedetomidine and morphine induced immobility in animals treated with MK-801 plus haloperidol, which then lost their righting reflex. These findings suggest that the immobility involves the inhibition of SP release in the spinal cord.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (1 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility

    • Author(s)
      Kikuchi, Nobuhito; Irifune, Masahiro; Shimizu, Yoshitaka; Yoshida, Keita; Morita, Katsuya; Kanematsu, Takashi; Morioka, Norimitsu; Nakata, Yoshihiro; Sakai, Norio
    • Journal Title

      Psychopharmacology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 選択的NMDAチャネル遮断とドパミン受容体拮抗作用の併用はマウスの正向反射を消失させるが、不動化は生じない2013

    • Author(s)
      入舩正浩
    • Organizer
      第28回中国・四国歯科麻酔研究会
    • Place of Presentation
      広島
    • Year and Date
      2013-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] プロポフォール誘発性εPKCトランスロケーションにおけるC1ドメインの役割2012

    • Author(s)
      宮原岳史,入舩正浩,酒井規雄,齋藤尚亮
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-10-06
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] プロテインキナーゼCのトランスロケーションと酵素活性に対するプロポフォールの効果2011

    • Author(s)
      宮原岳史,関貴弘,秀和泉,田中茂,齊藤尚亮,入船正浩,酒井規雄
    • Organizer
      第120回日本歯科薬理学会近畿部会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Pentobarbitalが引き起こす麻酔要素におけるGABA、グリシン、神経性コリン作動性、グルタミン酸およびサブスタンスP各神経の役割2011

    • Author(s)
      向井明里,入舩正浩,宮原岳史,大植香菜,石井裕明,土井充,清水慶隆,吉田啓太,福島怜子,西中村亮
    • Organizer
      第39回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-09
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] プロテインキナーゼC(PKC)のトランスロケーションと酵素活性に対するプロポフォールの影響2011

    • Author(s)
      宮原岳史,酒井規雄,入舩正浩
    • Organizer
      第39回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 選択的NMDAチャネル遮断とドパミン受容体拮抗作用の併用はマウスの正向反射を消失させるが、不動化は生じない

    • Author(s)
      入舩正浩
    • Organizer
      第28回中国・四国歯科麻酔研究会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Book] 全身麻酔薬の作用機序、歯科麻酔学第7版2011

    • Author(s)
      入舩正浩
    • Publisher
      医歯薬出版
    • Related Report
      2013 Final Research Report
  • [Book] 第7版 歯科麻酔学2011

    • Author(s)
      入舩正浩
    • Total Pages
      4
    • Publisher
      医歯薬出版
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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