| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
The role of substance P (SP) of the spinal cord in immobility as one of the general anesthetic factors was studied. Dexmedetomidine and morphine inhibit SP release from primary afferent neurons in the spinal cord. The selective N-methyl-D-aspartate (NMDA) channel blocker MK-801 is known to induce no loss of the righting reflex (LORR) and to stimulate catecholaminergic neurons in rodents, playing a crucial role in arousal. MK-801 in combination with a small dose of the dopamine (DA) receptor antagonist haloperidol dose-dependently produced LORR, but not immobility. Dexmedetomidine and morphine induced immobility in animals treated with MK-801 plus haloperidol, which then lost their righting reflex. These findings suggest that the immobility involves the inhibition of SP release in the spinal cord.
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