| Project/Area Number |
23592998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATORU Shintani 昭和大学, 歯学部, 教授 (80294429)
SEIJI Kondo 昭和大学, 歯学部, 准教授 (10432634)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 軟骨 / 骨 / ｍRNA / ヌクレオホスミン / 転写後制御 / RNA安定性 / B23 / RNA / 3'-UTR / 転写後遺伝子発現制御 / cis-element / 転写後発現制御 / cis-elemment |
|---|
| Research Abstract |
We successfully cloned mRNA, which bound to NPM protein in ATDC5 cells (a mouse chondrosarcoma cell line). The gene was found to bind to NPM by REMSA assay, and furthermore, to regulate the growth and differentiation of chondrocytes invivo, utilizing a gene expression and knock-down techniques.
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