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Participation of the adenosine receptor for amnesia effect of sedative and anesthetic agent

Research Project

Project/Area Number 23593000
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAsahi University (2013)
Tokyo Dental College (2011-2012)

Principal Investigator

SAKURAI Satoru  朝日大学, 歯学部, 教授 (50225843)

Co-Investigator(Kenkyū-buntansha) MIYAWAKI Takuya  岡山大学, 医歯(薬)学総合研究科, 教授 (00219825)
Co-Investigator(Renkei-kenkyūsha) ICHINOHE Tatsuya  東京歯科大学, 歯学部, 教授 (40184626)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアデノシン / ミダゾラム / プロポフォール / アミノフィリン / アデノシン受容体 / 健忘作用 / 健忘効果 / 鎮静効果
Research Abstract

Sedative/hypnotic effect of sedative and anesthetic agents occurs via Gamma-aminobutyric acid receptor. Moreover sedative and anesthetic agents potently inhibit adenosine uptake, thereby accumulating extracellular concentration of adenosine, and thus potentiate actions of adenosine. In this study, we evaluated the amnesic effect of adenosine (nuromodulator). Adenosine 5'-triphosphate (precursor of adenosine) administration enhanced amnesia and sedative effects during light sedation. Aminophylline administration antagonized the sedative effect but also the amnesic effect during deep sedation. These results clearly demonstrate that adenosine receptor stimulation potentiates the amnesic/sedative effect and adenosine receptor antagonism attenuate the amnesic/sedative effect.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 2012 2011

All Presentation (6 results)

  • [Presentation] フルマゼニル投与によるミダゾラム鎮静拮抗後に認められる再鎮静-アデノシンの関与-2013

    • Author(s)
      櫻井学
    • Organizer
      第41回日本歯科麻酔学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] フルマゼニル投与によるミダゾラム鎮静拮抗後に認められる再鎮静-アデノシンの関与-2013

    • Author(s)
      櫻井 学,後藤隆志,上野高広,名知ひかる,河合奈津子,智原栄一
    • Organizer
      第41回 日本歯科麻酔学会総会・学術大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミダゾラム鎮静からの回復―フルマゼニルとアミノフィリンの比較-2012

    • Author(s)
      櫻井学
    • Organizer
      第40回日本歯科麻酔学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ミダゾラム鎮静からの回復 -フルマゼニルとアミノフィリンの比較 第2報-2012

    • Author(s)
      櫻井 学,岡本聡太,久木留宏和,松木由紀子,一戸達也
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] ミダゾラム鎮静からの回復2011

    • Author(s)
      櫻井学
    • Organizer
      第39回日本歯科麻酔学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] ミダゾラム鎮静からの回復2011

    • Author(s)
      櫻井 学,岸本敏幸,征矢 学,久木留宏和,一戸達也,金子 譲
    • Organizer
      第39回日本歯科麻酔学会総会・学術大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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