Establishment of the newly bone regeneration therapy using polyhedra particles immobilized BMP-2 as a controlled release carrier for BMP-2
Project/Area Number |
23593002
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kanagawa Dental College |
Principal Investigator |
OMI yasushi 神奈川歯科大学, 歯学部, 助教 (10318892)
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Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Goichi 神奈川歯科大学, 歯学部, 准教授 (60199867)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 骨再生治療 / バイオマテリアル / 多角体 / BMP-2 / 徐放 / アテロコラーゲンスポンジ / コラーゲンスポンジ / bone regeneration / polyhedra / DDS / 骨再生 / アテロコラーゲン |
Research Abstract |
Bombyx mori cypovirus particles are embedded in micrometer-sized protein crystals called polyhedra and can remain infectious in harsh environmental conditions for years. But the remarkable stability of polyhedra can be applied on slow-release carriers of cytokines for tissue engineering. Here we show the complete healing in critical-sized bone defects by bone morphogenetic protein-2 (BMP-2) encapsulated polyhedra. Although absorbable collagen sponge (ACS) safely and effectively delivers recombinant human BMP-2 (rhBMP-2) into healing tissue, the current therapeutic regimens release rhBMP-2 at an initially high rate after which the rate declines rapidly. ACS impregnated with BMP-2 polyhedra had enough osteogenic activity to promote complete healing in critical-sized bone defects, but ACS with a high dose of rhBMP-2 showed incomplete bone healing, indicating that polyhedral microcrystals containing BMP-2 promise to advance the state of the art of bone healing.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Bone regeneration by polyhedral microcrystals from silkworm virus.2012
Author(s)
Matsumoto, G., Ueda, T., Shimoyama, J., Ijiri, H., Omi, Y., Yube, H., Sugita, Y., Kubo, K., Maeda, H., Kinoshita, Y., Arias, D. G.G., Shimabukuro, J., Kotani, E., Kawamata, S., and Mori, H.
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Journal Title
Sci. Rep.
Volume: 2巻
Issue: 1
Pages: 935-935
DOI
Related Report
Peer Reviewed
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