Research Project
Grant-in-Aid for Scientific Research (C)
Bombyx mori cypovirus particles are embedded in micrometer-sized protein crystals called polyhedra and can remain infectious in harsh environmental conditions for years. But the remarkable stability of polyhedra can be applied on slow-release carriers of cytokines for tissue engineering. Here we show the complete healing in critical-sized bone defects by bone morphogenetic protein-2 (BMP-2) encapsulated polyhedra. Although absorbable collagen sponge (ACS) safely and effectively delivers recombinant human BMP-2 (rhBMP-2) into healing tissue, the current therapeutic regimens release rhBMP-2 at an initially high rate after which the rate declines rapidly. ACS impregnated with BMP-2 polyhedra had enough osteogenic activity to promote complete healing in critical-sized bone defects, but ACS with a high dose of rhBMP-2 showed incomplete bone healing, indicating that polyhedral microcrystals containing BMP-2 promise to advance the state of the art of bone healing.
All 2014 2013 2012 2011 Other
All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Remarks (2 results)
Biomaterials
Volume: 35 Pages: 1326-1333
J Biomater Appl
Volume: 28 Pages: 1316-1324
J Biomater Appl.
Sci. Rep.
Volume: 2巻 Issue: 1 Pages: 935-935
10.1038/srep00935
http://www.nature.com/srep/2012/121206/srep00935/full/srep00935.html/
http://www.nature.com/srep/2012/121206/srep00935/full/srep00935.html