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Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

Research Project

Project/Area Number 23593004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTsurumi University

Principal Investigator

HAMADA Yoshiki  鶴見大学, 歯学部, 教授 (70247336)

Co-Investigator(Kenkyū-buntansha) SUZUKI Satsuki  日本歯科大学, 生命歯学部, 准教授 (10386253)
KUMAGAI Kenichi  鶴見大学, 歯学部, 助教 (10518129)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords変形性顎関節症 / STR/Ortマウス / 顎関節OA / STR/Ort マウス
Research Abstract

TMJs from 11 STR/ort mice euthanized at 30, 40, 50, 60, or 70 weeks of age, and from six CBA mice euthanized at 30, 40, or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using micro-computed tomography. At the age of 40 to 50 weeks, 66% of STR/ort mice losed of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by micro-computed tomography. The STR/ort mouse strain appears to be developed spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2014 2011 Other

All Journal Article (1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice International Journal of Oral & Maxillofacial Surgery2014

    • Author(s)
      Kenichi Kumagai, Satsuki Suzuki, Kanri, Yoriaki, Keisuke Fujii, Masahiro Wake, Ryuji Suzuki, and Yoshiki Hamada
    • Volume
      (in submission)
    • Related Report
      2013 Final Research Report
  • [Presentation] STR/Ortマウスにおける変形性顎関節症モデルとしての有用性について2011

    • Author(s)
      熊谷賢一,鈴木さつき,藤井恵介,鈴木隆二,濱田良樹
    • Organizer
      第24回一般社団法人日本顎関節学会総会・学術大会
    • Place of Presentation
      広島
    • Year and Date
      2011-07-22
    • Related Report
      2013 Final Research Report
  • [Presentation] STR/Ortマウスにおける変形性顎関節症モデルとしての有用性について2011

    • Author(s)
      熊谷賢一, 鈴木さつき, 藤井恵介, 鈴木隆二, 濱田良樹
    • Organizer
      第24回一般社団法人日本顎関節学会総会・学術大会
    • Place of Presentation
      広島(広島県民文化センター)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://ccs.tsurumi-u.ac.jp/oms

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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