Effect of dental pulp stem cells for the peripheral nerve paralysis
| Project/Area Number |
23593007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Misako 国立長寿医療研究センター, 歯科口腔先進医療開発センター再生歯科医療研究部, 部長 (20207773)
HIRATA Hitoshi 名古屋大学, 医学(系)研究科(研究院), 教授 (80173243)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 歯髄幹細胞移植 / 栄養因子 / シュワン細胞 / 末梢神経麻痺 / 再生 / 末梢神経再生 / 歯髄幹細胞 / 麻痺モデル |
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| Research Abstract |
We demonstrated that transplantation of dental pulp stem cells accelerated the healing of the injured peripheral nerve in the rat sciatic nerve defect model by morphological analyses. Dental pulp stem cells (DPSCs) expressed several neurotrophic/angiogenic factors both in vivo and in vitro. In addition, direct differentiation of DPSCs into Schwann cells was not shown in vivo. Transplanted DPSCs localized in the vicinity of the residual Schwann cells. Thus, these results suggest trophic effect of DPSCs on remaining/newly migrated Schwann cells, including enhanced proliferation and chemotaxis of Schwann cells and anti-apoptosis of adjacent cells.
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Report
(4 results)
Research Products
(9 results)
