| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Streptococcus sanguinis is a major member of the oral streptococci. In this study, we identified a unique cell surface filamentous structure named pili. We found that S. sanguinis pili are involved in biofilm formation. Further, pili subunit proteins are shown to bind salivary proteins such as amylase and salivary mucin. Another type-2 pili was also found in S. sanguinis. Further study revealed that type-2 pili-expressing oral streptococci are common habitants in healthy human. These results suggest that pili of oral streptococci contribute to the bacterial colonization in the human oral cavity.
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