Novel pathogenicity of pili of oral streptococci
Project/Area Number |
23593027
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Osaka University |
Principal Investigator |
NOBUO Okahashi 大阪大学, 歯学研究科(研究院), 准教授 (40150180)
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Co-Investigator(Kenkyū-buntansha) |
OOSHIMA Takashi 大阪大学, 大学院歯学研究科, 教授 (80116003)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | pili / oral streptococci |
Research Abstract |
Streptococcus sanguinis is a major member of the oral streptococci. In this study, we identified a unique cell surface filamentous structure named pili. We found that S. sanguinis pili are involved in biofilm formation. Further, pili subunit proteins are shown to bind salivary proteins such as amylase and salivary mucin. Another type-2 pili was also found in S. sanguinis. Further study revealed that type-2 pili-expressing oral streptococci are common habitants in healthy human. These results suggest that pili of oral streptococci contribute to the bacterial colonization in the human oral cavity.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis.2012
Author(s)
Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Ooshima T.
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Journal Title
Sci. Rep.
Volume: 2
Pages: article #332.
DOI
Related Report
Peer Reviewed
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[Journal Article] Complete genome sequence of the serotype k Streptococcus mutans strain LJ23.2012
Author(s)
Aikawa C, Furukawa N, Watanabe T, Minegishi K, Furukawa A, Eishi Y, Oshima K, Kurokawa K, Hattori M, Maruyama F, Nakagawa I, Ooshima T.
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Journal Title
J. Bacteriol.
Volume: 194(10)
Pages: 2754-2755.
DOI
Related Report
Peer Reviewed
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[Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation.2011
Author(s)
Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, Yamaguchi M, Kimura RK, Oiki E, Kawabata S, Ooshima T.
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Journal Title
Microb Pathog
Volume: 50(3-4)
Pages: 148-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Assembly mechanism of FCT region of type 1 pili in serotype M6 Streptococcus pyogenes.2011
Author(s)
Nakata M, Kimura KR, Sumitomo T, Wada S, Sugauchi A, Oiki E, Higashino M, Kreikemeyer B, Podbielski A, Okahashi N, Hamada S, Isoda R, Terao Y, Kawabata S.
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Journal Title
J BIol Chem
Volume: 286(43)
Pages: 37566-37577.
DOI
Related Report
Peer Reviewed
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[Presentation] Pili of oral Streptococcus sanguinis bind to salivary amylase and promotes biofilm formation2011
Author(s)
Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, Yamaguchi M, Kimura KR, Oiki E, Kawabata S, Ooshima T
Organizer
XIII International Congress of Bacteriology and Applied Microbiology
Place of Presentation
Sapporo, Japan
Year and Date
20110900
Related Report
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[Presentation] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote biofilm formation2011
Author(s)
Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, Yamaguchi M, Kimura KR, Oiki E,Kawabata S, Ooshima T
Organizer
XIII International Congress of Bacteriology and Applied Microbiology
Place of Presentation
Sapporo, Japan
Year and Date
2011. 9. 7.
Related Report
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