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The effect of the sensitivity in the esophagus mucous on a parafunction of the stomatognathic system

Research Project

Project/Area Number 23593036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKagoshima University

Principal Investigator

HIROSHI TOMONARI  鹿児島大学, 医歯(薬)学総合研究科, 助教 (70398288)

Co-Investigator(Kenkyū-buntansha) MIYAWAKI Shouichi  鹿児島大学, 大学院歯学総合研究科、歯科矯正学分野, 教授 (80295807)
YAGI Takakazu  鹿児島大学, 医学部・歯学部附属病院, 講師 (10346166)
KAMIMURA Hiroki  鹿児島大学, 大学院医歯学総合研究科・歯科矯正学分野, 助教 (50464467)
MAEDA Aya  鹿児島大学, 大学院医歯学総合研究科・歯科矯正学分野, 助教 (10457666)
UEDA Hirotaka  鹿児島大学, 医学部・歯学部附属病院, 助教 (10583445)
HARADA Syuitsu  鹿児島大学, 大学院歯学総合研究科、口腔生理学分野, 教授 (60128452)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords味覚受容メカニズム / 咀嚼機能 / パラファンクション / 顎口腔機能 / 胃食道逆流 / 口腔機能
Research Abstract

To clarify the mechanism of chemoreception in soft palate taste buds, we examined the co-expression of gustducin with taste receptors and the neural responses to several sweet and bitter compounds. Our results suggest that the regional and spices differences exist in both sweet and bitter signal transduction. Furthermore, we evaluate the morphology and the masticatory function in patients with malocclusion and normal subjects to reveal the relationship between the gastrointestinal disease and stomatognathic parafunction. Our findings suggest that the bite force is closely related to the masticatory jaw movements and masticatory performance in normal subject, and the patients with unilateral posterior scissors-bite malocclusion may behave the unique masticatory chewing pattern and muscle activity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (17 results) Remarks (2 results)

  • [Journal Article] Diverse contributions of Tas1r2/Tas2rs within the rat and mouse soft palate to sweet and bitter2014

    • Author(s)
      Tomonari H, Miura H, Ooki M, Nakayama A, Harada S
    • Journal Title

      Neurosci Lett

      Volume: 569 Pages: 63-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posterior scissors-bite: masticatory jaw movement and muscle activity2014

    • Author(s)
      Tomonari H, Kubota T, Yagi T, Kuninori T, Kitashima F, Uehara S, Miyawaki S
    • Journal Title

      Journal of oral rehabilitation

      Volume: Apr;41(4) Issue: 4 Pages: 257-65

    • DOI

      10.1111/joor.12148

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of maximum bite force on jaw movement during gummy jelly mastication2014

    • Author(s)
      Kuninori T, Tomonari H, Uehara S, Kitashima F, Yagi T, Miyawaki S
    • Journal Title

      Journal of oral rehabilitation

      Volume: May;41(5): Issue: 5 Pages: 338-45

    • DOI

      10.1111/joor.12149

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diverse contributions of Tas1r2/Tas2rs within the rat and mouse soft palate to sweet and bitter neural responses2014

    • Author(s)
      Hiroshi Tomonari, Hirohito Miura, Makoto Ooki, Ayumi Nakayama, Shuitsu Harada
    • Journal Title

      Neuroscience Letters

      Volume: 未定 Pages: 63-67

    • DOI

      10.1016/j.neulet.2014.03.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships between the root-crown ratio and the loss of occlusal contact and high mandibular plane angle in patients with open bite.2013

    • Author(s)
      Uehara S, Maeda A, Tomonari H, Miyawaki S.
    • Journal Title

      Angle orthodontics

      Volume: 83(1) Issue: 1 Pages: 36-42

    • DOI

      10.2319/042412-341.1

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gα-gustducin is extensively co-expressed with sweet and bitter taste receptors in both the soft palate and fungiform papillae but has a different functional significance2012

    • Author(s)
      Tomonari H, Miura H, Nakayama A, Matsumura E, Ooki M, Ninomiya Y, Harada S
    • Journal Title

      Chem senses

      Volume: 37(3) Pages: 241-51

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gα-gustducin is extensively co-expressed with sweet and bitter taste receptors in both the soft palate and fungiform papillae but has a different functional significance2012

    • Author(s)
      Tomonari H, Miura H, Nakayama A, Matsumura E, Ooki M, Ninomiya Y, Harada S
    • Journal Title

      Chem senses

      Volume: 37 Issue: 3 Pages: 241-251

    • DOI

      10.1093/chemse/bjr098

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of the basal cells in taste buds and taste cell differentiation2014

    • Author(s)
      三浦裕仁、中山歩、Jennifer K. Scott、友成博、大木誠、Linda A. Barlow、原田秀逸
    • Organizer
      第91回日本生理学会大会シンポジウム「口腔・脳・腸に発現する味覚センサーの部位特異性と機能連関」
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 下顎歯列後方部のディスクレパンシーを伴うアングルII級2類不正咬合の1治験例2014

    • Author(s)
      永山邦宏、友成博、北嶋文哲、宮脇正一
    • Organizer
      第9回九州矯正歯科学会大会症例展示
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] カスタムメイドリンガルブラケット矯正法と歯科矯正用アンカースクリューを用いて上顎大臼歯の遠心移動を行い非抜歯で治療したアングルII級叢生症例2014

    • Author(s)
      窪田健司、友成博、宮脇正一
    • Organizer
      第9回九州矯正歯科学会大会症例展示
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] カスタムメイドリンガルブラケット矯正法と歯科矯正用アンカースクリューを併用して非抜歯で上顎歯列の遠心移動を行った症例2014

    • Author(s)
      友成博、窪田健司、宮脇正一
    • Organizer
      第9回九州矯正歯科学会大会症例展示
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] 片側性臼歯部交叉咬合が咀嚼運動に及ぼす影響について2013

    • Author(s)
      池森宇泰、友成博、八木孝和、窪田健司、上原沢子、高田寛子、宮脇正一
    • Organizer
      第72回日本矯正歯科学会大会学術展示
    • Place of Presentation
      長野
    • Related Report
      2013 Final Research Report
  • [Presentation] 臼歯部鋏状咬合を伴う成人患者の咀嚼機能2013

    • Author(s)
      友成博、窪田健司、八木孝和、國則貴玄、北嶋文哲、上原沢子、宮脇正一
    • Organizer
      第72回日本矯正歯科学会大会学術展示
    • Place of Presentation
      長野
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨格性III級不正咬合患者における外科的矯正治療が咀嚼機能に及ぼす影響2013

    • Author(s)
      窪田健司、八木孝和、友成博、上原沢子、池森宇泰、宮脇正一
    • Organizer
      日本顎口腔機能学会第50回学術大会一般口演
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 片側性臼歯部交叉咬合を伴う患者の咀嚼運動について2013

    • Author(s)
      友成博、窪田健司、池森宇泰、上原沢子、北嶋文哲、八木孝和、宮脇正一
    • Organizer
      第8回九州矯正歯科学会学術大会学術展示
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] 鋏状咬合を伴う成人患者の咀嚼機能2013

    • Author(s)
      友成 博、窪田健司、八木孝和、国則貴玄、北嶋文哲、上原沢子、宮脇正一
    • Organizer
      日本矯正歯科学会
    • Place of Presentation
      長野県松本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 片側性臼歯部交叉咬合を伴う患者の咀嚼運動について2013

    • Author(s)
      友成博、窪田健司、池森宇泰、上原沢子、北嶋文哲、八木孝和、宮脇正一
    • Organizer
      第8回九州矯正歯科学会学術大会
    • Place of Presentation
      北九州市小倉
    • Related Report
      2012 Research-status Report
  • [Presentation] Regional differences in gustatory responses to bitter substances between the soft palate and fungiform papillae2012

    • Author(s)
      Ooki M, Tomonari H, Nakayama A, Miura H and Harada S
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT)
    • Place of Presentation
      ストックホルム,スウェーデン
    • Related Report
      2013 Final Research Report
  • [Presentation] 正常咬合者における最大咬合力の強弱がグミゼリー咀嚼時の下顎運動に及ぼす影響の解明2012

    • Author(s)
      國則貴玄,友成博,上原沢子,北嶋文哲,八木孝和,宮脇正一
    • Organizer
      日本顎口腔機能学会第49回学術大会一般口演
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人正常咬合者における咀嚼機能と歯列咬合状態との関連性について2012

    • Author(s)
      国則貴玄、友成博、北嶋文哲、八木孝和、宮脇正一
    • Organizer
      第7回九州矯正歯科学会大会学術展示
    • Place of Presentation
      大分
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨格性下顎前突症患者の咀嚼運動解析2012

    • Author(s)
      窪田健司、八木孝和、友成博、前田綾、宮脇正一
    • Organizer
      第7回九州矯正歯科学会大会学術展示
    • Place of Presentation
      大分
    • Related Report
      2013 Final Research Report
  • [Presentation] 正常咬合者における最大咬合力の強弱がグミゼリー咀嚼時の下顎運動に及ぼす影響の解明2012

    • Author(s)
      國則貴玄、友成 博、上原沢子、北嶋文哲、八木孝和、宮脇正一
    • Organizer
      顎口腔機能学会第49回学術大会
    • Place of Presentation
      北九州市小倉
    • Related Report
      2012 Research-status Report
  • [Presentation] 成人正常咬合者における咀嚼能率と最大咬合力、咬合接触面積、下顎運動および垂直的顎顔面形態との関連について2012

    • Author(s)
      國則貴玄、友成博、上原沢子、北嶋文哲、八木孝和、宮脇正一
    • Organizer
      九州矯正歯科学会
    • Place of Presentation
      大分県別府市
    • Related Report
      2011 Research-status Report
  • [Presentation] 軟口蓋と茸状乳頭における苦味情報伝達系の部位差(Regional differences in bitter taste signal transduction between the soft palate and fungiform papillae)2011

    • Author(s)
      三浦裕仁、友成博、中山歩、松村江梨子、大木誠、原田秀逸
    • Organizer
      第9回国際シンポジウム「味覚・嗅覚の分子神経機構」(The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception)
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Remarks] 鹿児島大学研究者総覧友成博

    • URL

      http://kuris.cc.kagoshima-u.ac.jp/408369.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 鹿児島大学大学院歯科矯正学講座研究活動

    • URL

      http://www.hal.kagoshima-u.ac.jp/kyousei/research1.htm

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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