| Project/Area Number |
23593041
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Health Sciences University of Hokkaido |
|---|
Principal Investigator |
SAITOH Masato 北海道医療大学, 歯学部, 教授 (50337036)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ABIKO Yoshihiro 北海道医療大学, 歯学部, 准教授 (90260819)
HIKITA Kazuhiro 北海道医療大学, 歯学部, 准教授 (20238281)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 抗菌ペプチド / ビタミンD / 活性型ビタミンD3 / タイトジャンクション / ディフェンシン / LL-37 / claudin / TER |
|---|
| Research Abstract |
The present study investigated whether vitamin D affect the promotion of wound healing, and the resistance to bacterial infection as chemical barriers in oral epithelium. Expression of antimicrobial peptides in epithelial keratinocyte cells were upregulated by the stimulation with vitamin D, indicating that vitamin D induced keratinocyte differentiation and barrier function. Wound healing of the rat oral mucosa was promoted to apply ointment supplementation of vitamin D. The results indicate that the application of vitamin D is efficacious of the wound healing and the barrier function in oral epithelium.
|
