| Project/Area Number |
23593042
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Takahiro 岩手医科大学, 歯学部, 研究員 (70599208)
ANDO Yoshinori 岩手医科大学, 歯学部, 助教 (40583662)
FUJIMURA Akira 岩手医科大学, 歯学部, 教授 (80173459)
MIURA Hiroyuki 岩手医科大学, 歯学部, 教授 (00048563)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | microRNA / Exosomes / Microvesicles / Osteoclasts / Osteoblasts / Macrophages / Microarray / Orthodontics / 骨芽細胞 / 破骨細胞 / exosomes / microvesicles / RANKL / THP-1 / RAW264.7 / MicroRNA / Osteoclast / Exosome / Osteoblast / Bone / TNF-alpha / 骨リモデリング / 時計遺伝子 / マイクロアレイ / 骨吸収 |
|---|
| Research Abstract |
The aim of this study is to develop a new treatment in orthodontics by focusing on clock genes which are regulated by microRNAs. Then we investigated osteoclasts, which play an important role in orthodontics. Specifically, we investigated eight miRNAs deemed important for osteoclastogenesis in our study: let-7e, miR-21, miR-33, miR-155, miR-210, miR-223, miR-378, and miR-1224. The results suggest that osteoclasts secrete extracellular microvesicles containing specific miRNAs, but that they do not contain the entire set of intracellular miRNAs.
|
