| Project/Area Number |
23593043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SAKURAI ATSUO 東京歯科大学, 歯学部, 講師 (90431759)
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| Co-Investigator(Kenkyū-buntansha) |
SHINTANI Seikou 東京歯科大学, 歯学部, 教授 (90273698)
MARUYAMA Fumito 東京医科歯科大学, 医歯学総合研究科, 准教授 (30423122)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 口腔内細菌 / レンサ球菌 / 乳酸桿菌 / 齲蝕 / 口腔疾患 / 口腔内細菌叢 / 哺乳齲蝕 |
|---|
| Research Abstract |
From 130 children, aged 2-7 years old, swab samples of teeth surfaces were collected after parental informed consent was obtained. Among Lactobacillus species, Lactobacillus salivarius was most frequently identified, followed by L. casei, L. fermentum, and L. gasseri. Especially, L. fermentum was predominantly identified from samples with high caries prevalence (dmf >6). Genetic diversity among the same Lactobacillus species in an individual sample is also related to high caries prevalence. In addition, analysis of oral microbiota in swab samples from children and their mothers revealed that oral microbiota in children showed much more abundance and diversity than in mothers. These characteristics might influence on a susceptibility of dental caries during early childhood age.
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