| Project/Area Number |
23593047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Terumi 日本歯科大学, 生命歯学部, 講師 (60515609)
SHIRASE Toshiomi1 日本歯科大学, 生命歯学部, 准教授 (20237018)
MITUI Sonoko 日本歯科大学, 生命歯学部, 助教 (10549083)
白瀬 敏臣 日本歯科大学, 生命歯学部, 准教授 (20247018)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 幼児 / 唾液 / フッ化物 / 齲蝕予防 / フッ化物製剤 / フッ化物濃度 / う蝕 / フローインジェクション / フローインジェクション分析法 / ミュータンスレンサ球菌 / 低濃度 / 乳酸桿菌 / 口腔衛生習慣 / 無機イオン / タンパク |
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| Outline of Final Research Achievements |
We measured the fluoride (F) ion concentration in infant saliva and examined the relationship between the F ion concentration and oral hygiene habits. The F ion dynamics in the saliva after the addition of a low-concentration F formulation in the saliva was also examined. We found that the average F ion concentration in Japanese infant saliva was 0.0083 ppmF. This concentration does not reach the minimum concentration necessary for remineralization. Therefore, Japanese infants required an aggressive use of the F formulation. A relationship between the brushing habits and the salivary F ion concentration was observed. The frequency of F formulated toothpaste use raised the F ion concentration in the saliva. When a low-concentration F formulation was introduced into the saliva, cations and proteins were found to decrease the free F ion concentration. According to these results, strategies to maintain the optimal F ion concentration in infant saliva must be developed and implemented.
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