Elucidation of salivary antioxidant protein for prevention of periodontitis-Analysis of antioxidant property and proteome-
| Project/Area Number |
23593049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
KOMATSU Tomoko 神奈川歯科大学, 歯学研究科(研究院), 講師 (20234875)
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| Co-Investigator(Kenkyū-buntansha) |
LEE Masaichi 神奈川歯科大学, 歯学研究科(研究院), 教授 (60220795)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIKAWA Masanobu 東海大学, 医学部, 講師 (90276791)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯周病 / 唾液タンパク質 / 活性酸素 / プロテオーム / Down症候群 / 電子スピン共鳴法 / ダウン症候群 / ヒスタチン |
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| Research Abstract |
The aim of the present study obtain the evidence, which is believed to have important implications for preventive medicine in the future, with physical activity as salivary antioxidant property of reactive oxygen species.
We investigated the antioxidant property of salivary protein, and the relationship among periodontal disease, salivary antioxidant activity and salivary antimicrobial activity for Candida albicans. As a result, the salivary proteins such as histatin 1,3,5 and PRP1, 2, 3, 4 would have antioxidant activity against hydroxyl radical. It was shown that the enhancement of antioxidant property and increase of histatin 5 was observed in saliva of aged and Down syndrome (DS) patients. These results suggested that it would be likely that the adaptive response in the biological antibacterial and antioxidant system againtst the growth of Candida albicans and increased histatin 5 with the progression of periodontal disease may be occurred by periodontitis, aging and DS patients.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Medical-grade collagen peptide in injectables provides antioxidant protection2013
Author(s)
Kobayashi K, Maehata Y, Okada Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Tokutomi F, Wada-Takahashi S, Komatsu T, Otsuka T, Takahashi SS, Lee MC
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Journal Title
Pharmaceutical Development and Technology
Volume: 29
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Medical-grade collagen peptide in injectables provides antioxidant protection.2013
Author(s)
Kobayashi K, Maehata Y, Okada Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Tokutomi F, Wada-Takahashi S, Komatsu T, Otsuka T, Takahashi SS, Lee MC
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Journal Title
Pharmaceutical Development and Technology
Volume: online
Issue: 2
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy2012
Author(s)
Yoshino F, Yoshida A, Wada-Takahashi S, Sugiyama S, Tokutomi F, Maehata Y, Miyamoto C, Komatsu T, Takahashi S-S, Kobayashi K, Lee M-C
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Journal Title
Archives of Oral Biology
Volume: vol. 57
Pages: 654-662
Related Report
Peer Reviewed
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[Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy2012
Author(s)
Yoshino F., Yoshida A., Wada-Takahashi S., Sugiyama S., Tokutomi F., Maehata Y., Miyamoto C., Komatsu T., Takahashi S-S., Kobayashi K., Lee M-C
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Journal Title
Archives of Oral Biology
Volume: 57
Pages: 654-662
Related Report
Peer Reviewed
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[Journal Article] Direct assessment of the antioxidant properties of midazolam by electron spin resonance spectroscopy2011
Author(s)
Hata M, Kobayashi K, Yoshino F, Yoshida A, Sugiyama S, Miyamoto C, Tokutomi F, Maehata Y, Wada-Takahashi S, Takahashi SS, Komatsu T, Yoshida K, Lee MC
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Journal Title
Journal of Anesthesia
Volume: vol. 25
Pages: 765-769
NAID
Related Report
Peer Reviewed
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[Journal Article] Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy2011
Author(s)
Kobayashi K, Maehata Y, Kawamura Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Wada-Takahashi S, Komatsu T, Takahashi S, Lee M-CL
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Journal Title
Journal of Pharmacological Sciences
Volume: vol. 116
Pages: 97-106
NAID
Related Report
Peer Reviewed
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[Presentation] Down症候群患者における口腔内Candida菌と唾液中活性酸素種の関連性2013
Author(s)
小松知子,植田郁子,大塚剛郎,早野愛,坂本貴史,中村ミゲル,村井朋代,井田侑子,池田正一,宮城敦,浜田信城,李昌一
Organizer
第30回日本障害者歯科学会総会および学術大会
Place of Presentation
神戸
Related Report
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[Presentation] 唾液ヒスタチン5含有量とCandida菌分離頻度および口腔内所見との関連性‐若年ダウン症候群患者における検討‐2012
Author(s)
小松知子,植田郁子,坂本貴史,伊藤愛,中村ミゲル,村井朋代,井田侑子,池田正一,宮城 敦, 浜田信城,李昌一
Organizer
第29回日本障害者歯科学会
Place of Presentation
札幌
Related Report
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[Presentation] Down症候群患者の口腔Candida菌の分離頻度と日常生活動作の関連性2012
Author(s)
伊藤愛,小松知子,植田郁子,坂本貴史,高瀬幸子,井田侑子,グリーナンせつゑ,池田正一, 李 昌一,宮城 敦,浜田信城
Organizer
第29回日本障害者歯科学会
Place of Presentation
札幌
Related Report
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[Presentation] 電子スピン共鳴法による唾液タンパク質の抗酸化能評価2011
Author(s)
小松知子,小林 杏,吉野文彦,前畑洋次郎,宮 本千央,徳富文彬,杉山秀太,吉田彩佳,高橋聡 子,高橋俊介,前谷崇志,川村陽介,辻村 傑,岡 田永三,岡田康江,西村成文,宮城 敦,李 昌一
Organizer
第11回抗加齢医学会
Place of Presentation
京都
Related Report
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[Presentation] 高齢Down症候群患者のADLと歯科的所見との関連性2011
Author(s)
小松知子,植田郁子,坂本貴史,熊田秀文,鶴谷 俊輔,伊藤 愛,高野知子,岡部愛子,小林 杏, 前谷崇志,浜田信城,宮城 敦,池田正一,李昌 一
Organizer
第12回抗加齢歯科医学会
Place of Presentation
横浜
Related Report
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