Functional analysis in oral cavity of human saliva Galectin-1 and drug deploy of the protein

• Project/Area Number: 23593051
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: SASAGURI KENICHI 神奈川歯科大学, 歯学研究科(研究院), 講師 (10235286)
• Co-Investigator(Kenkyū-buntansha): KADOYA Toshihiko 前橋工科大学, 工学部・生物工学科, 教授 (40551875)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Galectin-１ / saliva / ガレクチンー1 / P.gingivalis / マクロファージ / Galectin-1 / なし

Research Abstract

Galectin-1(Gal-1) is a multifunctional protein that is widely distributed thoughout the body, and recently has been found to inhibit the secretion of inflammatory cytokines by macrophages. In addition, since Gal-1 has been found to be secreted in human saliva, the functions of Gal-1 in the oral cavity were analyzed by using P.gingivalis to prepare rats with periodontal disease. The results suggested that Gal-1 may have an inhibitory effect on bone resorption caused by experimental periodontitis at concentrations 100 times higher than those found in the rat's oral cavities. In the future, we will elucidate the mechanism behind the inhibitory effect of Gal-1 on periodontitis, and will examine the possibility of the future expansion of its use in the development of new drugs.

Research Products

• [Presentation]
  • Author(s): 門屋利彦,岩本真由子,小泉創,堀江秀典,越野江利子,宮原初美,山本利春,笹栗健一