| Project/Area Number |
23593052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NODA Kouji 鶴見大学, 歯学部, 臨床教授 (10148059)
ARAI Chihiro 鶴見大学, 歯学部, 助教 (10460221)
HANADA Nobuhiro 鶴見大学, 歯学部, 教授 (70180916)
NOMURA Yoshiaki 鶴見大学, 歯学部, 准教授 (90350587)
WADA Satoshi 鶴見大学, 歯学部, 助教 (20581119)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯の移動 / 牽引側歯根膜 / 初期変化 / 免疫系細胞 / 単球、マクロファージ / MMP12 / osterix / アルカリフォスファターゼ / エラスチン / コラーゲン線維 / 歯根膜 / 免疫関連因子 / 遺伝子発現 |
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| Research Abstract |
Tissue reaction of the tension zone of periodontal ligament ( PDL ) during orthodontic tooth movement has been simplified as tugging of PDL fibers and bone formation. However, PDL fibers in the tension zone are forced to strong tugging, which causes involvement of defense system. We examined an involvement of immune system in the tension zone of PDL in early stage of tooth movement, using histological and immunohistochemical methods. Periodontal space was enlarged to more than 130 % and the PDL fibers showed a strong tugging aspect 6 hours after initiation of tooth movement. ED1 positive cells ( macrophage and monocyte ) were increased. However, fibroblasts also showed localization of IL-1B and MMP12. This indicats that fibroblasts involve in defense reaction of the PDL, prior to rearrangement of the PDL and bone formation on the alveolar bone in the very early stage of periodontal reaction in the tension zone.
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