Mechanisms Linking Periodontitis to Atherosclerotic Diseases

• Project/Area Number: 23593056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: KOICHI TABETA 新潟大学, 医歯学系, 助教 (20401763)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Kazuhisa 新潟大学, 医歯学系, 教授 (00182478)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯周病 / 核酸抗原 / 動脈硬化症 / 歯周炎 / 歯学 / Unc93b

Research Abstract

The aim of this study is to clarify the mechanisms by which oral infection in periodontitis affects systemic disease, especially focusing atherosclerosis. Oral infection induce gut inflammation in low level and enhance atherogenesis. Using unc93b1 mutant, non-responder to nuclear antigens such as DNA and RNA antigens failed to produce IgA against P. gingivalis. Therefore, this study have shown the significance of nuclear antigens in gut immune response to oral infected bacteria.

Research Products

• [Journal Article] Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis (2014)
  • Author(s): Aoki-Nonaka Y, Nakajima T, Miyauchi S, Miyazawa H, Yamada H, Domon H, Tabeta K, Yamazaki K
  • Journal Title: J Periodontal Res Volume: 49(1) Pages: 69-76
  • Peer Reviewed
• [Journal Article] Current evidence and biological plausibility linking periodontitis to atherosclerotic cardiovascular disease (2014)
  • Author(s): Koichi Tabeta, Hiromasa Yoshie, Kazuhisa Yamazaki
  • Journal Title: Japanese Dental Science Review Volume: 未定
  • NAID: 50009442958
  • Peer Reviewed
• [Journal Article] Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice" (2013)
  • Author(s): Tabeta K, Hoebe K, Janssen EM, Xia Y, Beutler B
  • Journal Title: Nat Immunol Volume: 14(11) Pages: 1102-3
  • Peer Reviewed
• [Journal Article] Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis (2013)
  • Author(s): Domon H, Tabeta K, Nakajima T, Yamazaki K
  • Journal Title: J Periodontal Res
  • Peer Reviewed
• [Journal Article] A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice (2013)
  • Author(s): Huang H, Zhao P, Arimatsu K, Tabeta K, Yamazaki K, Krieg L, Fu E, Zhang T, Du X
  • Journal Title: G3 (Bethesda) Volume: 3(10) Pages: 1687-95
  • Peer Reviewed
• [Journal Article] Profiling biomarkers in gingival crevicular fluid using multiplex bead immunoassay (2013)
  • Author(s): Shimada Y, Tabeta K, Sugita N, Yoshie H
  • Journal Title: Arch Oral Biol Volume: 58(6) Pages: 724-30
  • Peer Reviewed
• [Journal Article] ENU-induced phenovariance in mice : inferences from 587 mutations (2012)
  • Author(s): Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B
  • Journal Title: BMC Res Notes Volume: 5 Pages: 577-577
  • Peer Reviewed
• [Journal Article] Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice (2012)
  • Author(s): Miyazawa H, Tabeta K, Miyauchi S, Aoki-Nonaka Y, Domon H, Honda T, Nakajima T, Yamazaki K
  • Journal Title: Lipids Health Dis Volume: 11 Pages: 121-121
  • Peer Reviewed
• [Journal Article] Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis (2012)
  • Author(s): Miyashita H, Honda T, Maekawa T, Takahashi N, Aoki Y, Nakajima T, Tabeta K, Yamazaki K
  • Journal Title: Arch Oral Biol Volume: 57(6) Pages: 820-9
  • Peer Reviewed
• [Journal Article] Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE shl mice (2012)
  • Author(s): Miyauchi S, Maekawa T, Aoki Y, Miyazawa H, Tabeta K, Nakajima T, Yamazaki K
  • Journal Title: J Periodontal Res Volume: 47(3) Pages: 402-8
  • Peer Reviewed
• [Journal Article] Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice (2012)
  • Author(s): Miyazawa H, Domon H, et al
  • Journal Title: Lipids Health Dis. Volume: 11 Issue: 1 Pages: 121-121
  • DOI: 10.1186/1476-511x-11-121
  • Peer Reviewed
• [Journal Article] Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE(shl) mice. (2011)
  • Author(s): Miyauchi S, Maekawa T, Aoki Y, Miyazawa H, Tabeta K, Nakajima T, Yamazaki K.
  • Journal Title: J Periodontal Res. Volume: Nov 20. Pages: 1600-1765
  • Peer Reviewed
• [Presentation] Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile.
  • Author(s): KOICHI TABETA, T. MAEKAWA, N. TAKAHASHI, Y. AOKI, H. MIYASHITA, S. MIYAUCHI, H. MIYAZAWA, T. NAKAJIMA, K. YAMAZAKI,
  • Organizer: The 2011 Gordon Research Conference on Periodontal Diseases
  • Place of Presentation: Shallot, NC, USA
• [Presentation] 歯周炎と動脈硬化性疾患の関連メカニズムについて- P. gingivalis の脂質代謝変動への作用-
  • Author(s): 多部田 康一
  • Organizer: 第１３５回日本歯科保存学会秋季学術大会(招待講演)
  • Place of Presentation: 大阪