| Project/Area Number |
23593059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shigeki 広島大学, 大学院医歯薬保健学研院, 助教 (30549762)
YAMASHITA Akiko 広島大学, 大学院医歯薬保健学研院, 助教 (70511319)
NISHIMURA Fusanori 九州大学, 大学院歯学研究院, 教授 (80208222)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | カテプシンL / 多毛症 / ヒト歯肉線維芽細胞 / カテプシン / ヒト歯肉繊維芽細胞 / 歯肉増殖症 / ライソゾーム酵素 / カテプシン-L |
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| Research Abstract |
Recently, it has revealed that Cathepsin activities can invole with the onset of gingival hyperplasia. And some gingival hyperplasia patients are reported to have severe hypertrichosis. Therefore, the purpose of this study is to evaluate cathepsin activities of fibroblasts from patients with gingival hyperplasia and hypertrichosis and healthy person.
The patients' cells showed decrease in Cathepsin-L activities, and increase in Cathepsin-B activities. Furthermore, Cathepsin-L knockout mice have abnormal turn over of hair follicle.
From these results, it is suggested that decreased activity of Cathepsin may play a role to onset of hypertrichosis.
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