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Analysis of patients with gingival hyperplasia and hypertrichosis

Research Project

Project/Area Number 23593059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionHiroshima University

Principal Investigator

ARAKAWA Makoto  広島大学, 大学病院, 助教 (60379881)

Co-Investigator(Kenkyū-buntansha) SUZUKI Shigeki  広島大学, 大学院医歯薬保健学研院, 助教 (30549762)
YAMASHITA Akiko  広島大学, 大学院医歯薬保健学研院, 助教 (70511319)
NISHIMURA Fusanori  九州大学, 大学院歯学研究院, 教授 (80208222)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
KeywordsカテプシンL / 多毛症 / ヒト歯肉線維芽細胞 / カテプシン / ヒト歯肉繊維芽細胞 / 歯肉増殖症 / ライソゾーム酵素 / カテプシン-L
Research Abstract

Recently, it has revealed that Cathepsin activities can invole with the onset of gingival hyperplasia. And some gingival hyperplasia patients are reported to have severe hypertrichosis. Therefore, the purpose of this study is to evaluate cathepsin activities of fibroblasts from patients with gingival hyperplasia and hypertrichosis and healthy person.
The patients' cells showed decrease in Cathepsin-L activities, and increase in Cathepsin-B activities. Furthermore, Cathepsin-L knockout mice have abnormal turn over of hair follicle.
From these results, it is suggested that decreased activity of Cathepsin may play a role to onset of hypertrichosis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] 多毛症を合併した先天性歯肉増殖症患者由来歯肉線維芽細胞のカテプシン活性の検討2013

    • Author(s)
      荒川真、半井英雄、山下明子、岩本義博、鈴木茂樹、西村英紀
    • Organizer
      日本歯周病学会2013年度春季学術大会(第56回)
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多毛症を合併した先天性歯肉増殖症患者由来歯肉線維芽細胞のカテプシン活性の検討2013

    • Author(s)
      荒川真、半井英雄、山下明子、岩本義博、鈴木茂樹、西村英紀
    • Organizer
      日本歯周病学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多毛症を合併した先天性歯肉増殖症患者由来歯肉線維芽細胞のカテプシン活性の検討2013

    • Author(s)
      荒川 真
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks] 該当なし

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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