The regulation of periodontal inflammation based on the inflammasomes activated by periodontal pathogens.
Project/Area Number |
23593066
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontal dentistry
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Research Institution | Fukuoka Dental College (2014) Nagasaki University (2011-2013) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HARA Yoshitaka 長崎大学, 大学院医歯薬学総合研究科, 教授 (60159100)
YOSHIMURA Atsutoshi 長崎大学, 大学院石薬学総合研究科, 准教授 (70253680)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 歯周病原細菌 / インフラマソーム / NLRP3 / カスパーゼ1 / NALP3 / カスパーゼ-1 / 歯周病源細菌 / IL-1β / NLRP1 / NLRC4 / ペプチドグリカン / IL-18 |
Outline of Final Research Achievements |
TInterleukin (IL)-1 is an inflammatory cytokine associated with periodontal break down and alveolar bone resorption, therefore the regulation of IL-1is important to inhibit onset/progression of periodontal disease. IL-1 secretion induced with periodontal pathogens (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum) is inhibited by the pretreatment with both Ac-YVAD-CMK and glyburide, indicating that IL-1 activation is dependent on both caspase-1 and NLRP3. These results indicate that the possibility of novel periodontal treatment that is targeted for caspase-1 and NLRP3.
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide regulates bone sialoprotein gene transcription.2012
Author(s)
Li X, Zhou L, Takai H, Sasaki Y, Mezawa M, Li Z, Wang Z, Yang L, Wang S, Matsumura H, Kaneko T, Yoshimura A, Ogata Y.
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Journal Title
Journal of Cellular Biochemistry
Volume: 113
Pages: 2822-2834
Related Report
Peer Reviewed
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