Multiple analysis of periodontal condition changes before and after smoking cessation.
| Project/Area Number |
23593072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
NUMABE yuihiro 日本歯科大学, 生命歯学部, 教授 (90198557)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hiroshi 日本歯科大学, 生命歯学部, 准教授 (30184683)
ISHIGURO Kazumi 日本歯科大学, 生命歯学部, 助教 (20508486)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 禁煙 / 歯肉溝滲出液 / 好中球 / エラスターゼ / 唾液 / コチニン / 禁煙支援 / 免疫 / 喫煙 / AST / 潜血 / 歯周病 / 歯肉炎 / 歯学 / 酵素 |
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| Research Abstract |
The relationship between periodontal destruction and smoking has been demonstrated by epidemiological evidence. However the mechanism of this effect is unknown and it may be related to a host defense reaction. The aim of this study is to investigate the effects of smoking cessation on the host defense mechanism in gingival crevicular fluid (GCF) using multiple analysis.
The neutrophil elastase activity in GCF (one of inflammation markers) was measured with a low molecular weight substrate and amount of cotinine in saliva was measured with ELISA. From the results, the elastase activity in GCF was not changed in short term smoking cessation. Furthermore it was shown that temporary smoking cessation does not contribute to an improvement of periodontal tissue and it needs more long period.
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Report
(4 results)
Research Products
(29 results)
