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Multiple analysis of periodontal condition changes before and after smoking cessation.

Research Project

Project/Area Number 23593072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

NUMABE yuihiro  日本歯科大学, 生命歯学部, 教授 (90198557)

Co-Investigator(Kenkyū-buntansha) ITO Hiroshi  日本歯科大学, 生命歯学部, 准教授 (30184683)
ISHIGURO Kazumi  日本歯科大学, 生命歯学部, 助教 (20508486)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords禁煙 / 歯肉溝滲出液 / 好中球 / エラスターゼ / 唾液 / コチニン / 禁煙支援 / 免疫 / 喫煙 / AST / 潜血 / 歯周病 / 歯肉炎 / 歯学 / 酵素
Research Abstract

The relationship between periodontal destruction and smoking has been demonstrated by epidemiological evidence. However the mechanism of this effect is unknown and it may be related to a host defense reaction. The aim of this study is to investigate the effects of smoking cessation on the host defense mechanism in gingival crevicular fluid (GCF) using multiple analysis.
The neutrophil elastase activity in GCF (one of inflammation markers) was measured with a low molecular weight substrate and amount of cotinine in saliva was measured with ELISA. From the results, the elastase activity in GCF was not changed in short term smoking cessation. Furthermore it was shown that temporary smoking cessation does not contribute to an improvement of periodontal tissue and it needs more long period.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (10 results) Book (7 results)

  • [Journal Article] Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy2014

    • Author(s)
      Ito H、Sekino S、Murakashi E、Iguchi( Ishiguro) K、Hashimoto S、Numabe Y
    • Journal Title

      Odontology

      Volume: vol.102 Pages: 550-561

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy.2014

    • Author(s)
      Ito H, Numabe Y, Sekino S, Murakashi E, Iguchi H, Hashimoto S, Sasaki D
    • Journal Title

      Odontology

      Volume: 102 Issue: 1 Pages: 550-561

    • DOI

      10.1007/s10266-012-0090-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 短期間禁煙がGCFエラスターゼ活性と唾液成分に及ぼす影響2013

    • Author(s)
      伊藤弘、小川智久、沼部幸博
    • Journal Title

      歯科人間ドック学会会誌

      Volume: 8巻 Pages: 61-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 短期間禁煙がGCFエラスターゼ活性と唾液成分に及ぼす影響2013

    • Author(s)
      伊藤 弘、小川智久、沼部幸博
    • Journal Title

      日歯ドック誌

      Volume: 8 Pages: 61-67

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科と喫煙 その22013

    • Author(s)
      沼部幸博
    • Journal Title

      りぶる

      Volume: 377 Pages: 64-65

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 歯科と喫煙 その12013

    • Author(s)
      沼部幸博
    • Journal Title

      りぶる

      Volume: 376 Pages: 56-57

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 喫煙の歯周組織環境に与える影響-基礎的背景-2012

    • Author(s)
      沼部幸博
    • Journal Title

      臨床環境医学

      Volume: 21巻 Pages: 183-191

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喫煙の歯周組織環境に与える影響-基礎的背景-2012

    • Author(s)
      沼部幸博
    • Journal Title

      臨床環境医学

      Volume: 21 Pages: 183-191

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯科人間ドックにおけるGCF測定導入に向けて-特にその酵素活性の安定を図るために-2011

    • Author(s)
      伊藤弘、橋本修一、沼部幸博
    • Journal Title

      歯科人間ドック学会会誌

      Volume: 6巻 Pages: 17-22

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ポジションペーパー喫煙の歯周組織に対する影響2011

    • Author(s)
      大森みさき、両角俊哉、稲垣幸司、横田誠、沼部幸博、佐藤聡、伊藤弘、王宝禮、上田雅俊、山田了、伊藤公一
    • Journal Title

      日本歯周病学会会誌

      Volume: 53巻 Pages: 40-49

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯科人間ドックにおけるGCF測定導入に向けて -特にその酵素活性の安定を図るために-2011

    • Author(s)
      伊藤 弘、橋本修一、沼部幸博
    • Journal Title

      日本歯科人間ドック学会誌

      Volume: 6 Pages: 17-22

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ポジションペーパー 喫煙の歯周組織に対する影響.2011

    • Author(s)
      大森みさき、両角俊哉、稲垣幸司、 横田 誠、沼部幸博、佐藤 聡、伊藤 弘、王 宝禮、上田雅俊、山田 了、伊藤公一
    • Journal Title

      日本歯周病学会会誌

      Volume: 53 Pages: 40-49

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 歯周疾患のスクリーニング検査としてアンケート調査および唾液検査の有用性2013

    • Author(s)
      伊藤弘、関野愉、村樫悦子、石黒一美、沼部幸博、戸円智幸、橋本修一、佐々木大輔、八重柏隆、國松和司、高井英樹、目澤優、小方頼昌、渡邊久、萩原さつき、和泉雄一、廣島佑香、木戸淳一、永田俊彦
    • Organizer
      秋季日本歯科保存学会
    • Place of Presentation
      秋田
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 喫煙は歯周治療における超過医療費因子となりうるか?2013

    • Author(s)
      伊藤弘、沼部幸博、橋本修一、森田学、稲垣幸司、埴岡隆、王宝禮、藤井健男、山本龍生、両角俊哉
    • Organizer
      秋季日本歯周病学会
    • Place of Presentation
      前橋
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯肉溝滲出液(GCF)中Hemoglobin(Hb)検出を応用した歯周病迅速診断キットの概要2013

    • Author(s)
      沼部幸博、伊藤弘、石井マイケル大宜、倉治竜太郎、橋本修一
    • Organizer
      秋季日本歯周病学会
    • Place of Presentation
      前橋
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Alterations of salivary PMN functions after cigarette smoking2012

    • Author(s)
      Numabe Y、Ito H
    • Organizer
      Japan China Dental Ccnference 2012
    • Place of Presentation
      Sichuan University, Chengdu, China
    • Year and Date
      2012-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Smoking and GCF neutrophil activity2012

    • Author(s)
      Ito H、Numabe Y
    • Organizer
      Japan China Dental Ccnference 2012
    • Place of Presentation
      Sichuan University, Chengdu, China
    • Year and Date
      2012-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Alterations of salivary PMN functions after cigarette smoking.2012

    • Author(s)
      Numabe Yukihiro, Ito Hiroshi
    • Organizer
      Japan China Dental Ccnference 2012
    • Place of Presentation
      Sichuan University, Chengdu, China
    • Related Report
      2012 Research-status Report
  • [Presentation] Smoking and GCF neutrophil activity.2012

    • Author(s)
      Ito Hiroshi, Numabe Yukihiro
    • Organizer
      Japan China Dental Ccnference 2012
    • Place of Presentation
      Sichuan University, Chengdu, China
    • Related Report
      2012 Research-status Report
  • [Presentation] 歯肉溝滲出液(GCF)中Hemoglobin(Hb)検出を応用した歯周病迅速診断キットの概要

    • Author(s)
      沼部幸博、伊藤 弘、石井マイケル大宜、倉治竜太郎、橋本修一
    • Organizer
      平成25年度日本歯周病学会秋季大会
    • Place of Presentation
      群馬 前橋テルサ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 喫煙は歯周治療における超過医療費因子となりうるか?

    • Author(s)
      伊藤 弘、沼部幸博、橋本修一、森田 学、稲垣幸司、埴岡 隆、王 宝禮、藤井健男、山本龍生、両角俊哉
    • Organizer
      平成25年度日本歯周病学会秋季大会
    • Place of Presentation
      群馬 前橋テルサ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周疾患のスクリーニング検査としてアンケート調査および唾液検査の有用性

    • Author(s)
      伊藤 弘、関野 愉、村樫悦子、石黒一美、沼部幸博、戸円智幸、橋本修一、佐々木大輔、 八重柏隆、國松和司、高井英樹、目澤 優、小方頼昌、渡邊 久、萩原さつき、和泉雄一、廣島佑香、木戸淳一、永田俊彦
    • Organizer
      平成25年度秋季日本歯科保存学会
    • Place of Presentation
      秋田県 秋田県総合生活文化会館
    • Related Report
      2013 Annual Research Report
  • [Book] ザペリオドントロジー第2版2014

    • Author(s)
      和泉雄一、沼部幸博、山本松男、木下淳博編集主幹(分担執筆)
    • Total Pages
      280
    • Publisher
      医師訳出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] ザ•ペリオドントロジー 第2版2014

    • Author(s)
      和泉雄一、沼部幸博、山本松男、木下淳博
    • Total Pages
      280
    • Publisher
      永末書店
    • Related Report
      2013 Annual Research Report
  • [Book] 歯と口の力UPナビいつまでも自分の歯で食べるために2013

    • Author(s)
      沼部幸博
    • Total Pages
      32
    • Publisher
      東京法規出版
    • Related Report
      2013 Final Research Report
  • [Book] 高齢期の歯と口の健康づくり2013

    • Author(s)
      沼部幸博
    • Total Pages
      12
    • Publisher
      東京法規出版
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Book] 歯と口の力UP ナビ いつまでも自分の歯で食べるために2013

    • Author(s)
      沼部幸博
    • Total Pages
      32
    • Publisher
      東京法規出版
    • Related Report
      2013 Annual Research Report
  • [Book] 禁煙あなたのお口と全身の健康2012

    • Author(s)
      沼部幸博
    • Total Pages
      88
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 禁煙 あなたのお口と全身の健康2012

    • Author(s)
      沼部 幸博
    • Total Pages
      88
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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