| Project/Area Number |
23593073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shun-suke 神奈川歯科大学, 歯学研究科(研究院), 准教授 (60206810)
LEE Masaichi Chang-il 神奈川歯科大学, 歯学研究科(研究院), 教授 (60220795)
HAMADA Nobushiro 神奈川歯科大学, 歯学研究科(研究院), 教授 (20247315)
MATSUO Masato 神奈川歯科大学, 歯学研究科(研究院), 准教授 (30190416)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周病 / 循環器疾患 / 活性酸素 / 高血圧 / 循環器障害 / 活性酸素種 |
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| Research Abstract |
We assessed alteration of vascular endothelial function by measuring gingival reactive hyperemia (GRH) on the oral microcirculation of lifestyle-related disease animal models such as Stroke-Prone Spontaneously Hypertensive Rat (SHRSP). GRH was measured by using a laser Doppler flowmetry on Wistar Kyoto rats (WKY), SHRSP, Porphyromonas gingivalis(P.g) infection to WKY (WKY+P.g), and P.g infection to SHRSP (SHRSP+P.g), respectively. GRH was decreased in WKY+P.g compared to WKY. However, GRH was significantly increased in SHRSP+P.g compared to SHRSP.
Our results suggested that alteration of vascular endothelial function may occur in gingival tissue on both periodontitis and stroke animal models.
Furthermore we examined P. gingivalis-induced alveolar bone loss in SHRSP and WKY. The results obtained confirmed that P. gingivalis-induced alveolar bone loss was increased in periodontal disease and/or "hypertension and stroke", which may have been associated with oxidative stress.
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