Oral Vascular Functions Are Altered in Periodontitis and/or Stroke Disease Model

• Project/Area Number: 23593073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: WADA-TAKAHASHI Satoko 神奈川歯科大学, 歯学研究科(研究院), 講師 (30301592)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Shun-suke 神奈川歯科大学, 歯学研究科(研究院), 准教授 (60206810) ; LEE Masaichi Chang-il 神奈川歯科大学, 歯学研究科(研究院), 教授 (60220795) ; HAMADA Nobushiro 神奈川歯科大学, 歯学研究科(研究院), 教授 (20247315) ; MATSUO Masato 神奈川歯科大学, 歯学研究科(研究院), 准教授 (30190416)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯周病 / 循環器疾患 / 活性酸素 / 高血圧 / 循環器障害 / 活性酸素種

Research Abstract

We assessed alteration of vascular endothelial function by measuring gingival reactive hyperemia (GRH) on the oral microcirculation of lifestyle-related disease animal models such as Stroke-Prone Spontaneously Hypertensive Rat (SHRSP). GRH was measured by using a laser Doppler flowmetry on Wistar Kyoto rats (WKY), SHRSP, Porphyromonas gingivalis(P.g) infection to WKY (WKY+P.g), and P.g infection to SHRSP (SHRSP+P.g), respectively. GRH was decreased in WKY+P.g compared to WKY. However, GRH was significantly increased in SHRSP+P.g compared to SHRSP.
Our results suggested that alteration of vascular endothelial function may occur in gingival tissue on both periodontitis and stroke animal models.
Furthermore we examined P. gingivalis-induced alveolar bone loss in SHRSP and WKY. The results obtained confirmed that P. gingivalis-induced alveolar bone loss was increased in periodontal disease and/or "hypertension and stroke", which may have been associated with oxidative stress.

Research Products

• [Journal Article] Alteration of the redoxstate with reactive oxygen species for 5-fluorouracil- induced oral mucositis in hamsters (2013)
  • Author(s): Yoshino F, Yoshida A, Nakajima A, Wada-Takahashi S, Takahashi S-S, Lee M-C
  • Journal Title: PLoS ONE Volume: 8(12) Issue: 12 Pages: 1-6
  • DOI: 10.1371/journal.pone.0082834
  • Peer Reviewed
• [Journal Article] Medical-grade collagen peptide in injectables provides antioxidant protection. (2013)
  • Author(s): Kobayashi K, Maehata Y, Okada Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Tokutomi F, Wada-Takahashi S, Komatsu T, Otsuka T, Takahashi SS, Lee MC
  • Journal Title: Pharmaceutical Development and Technology Volume: online Issue: 2 Pages: 1-8
  • DOI: 10.3109/10837450.2013.860547
  • Peer Reviewed / Open Access
• [Journal Article] Reactive Oxygen Species Production in Mitochondria of Human Gingival Fibroblast Induced by Blue Light Irradiation (2013)
  • Author(s): Yoshida A, Yoshino F, Makita T, Maehata Y, Higashi K, Miyamoto C, Wada-Takahashi S, Takahashi S-S, Takahashi O, Lee M-C
  • Journal Title: Journal of Photochemistry and Photobiology B: Biology Volume: 129 Pages: 1-5
  • DOI: 10.1016/j.jphotobiol.2013.09.003
  • Peer Reviewed
• [Journal Article] 脳卒中易発症性高血圧自然発症ラット(SHRSP)に対するAOBの効果 (2013)
  • Author(s): 徳富文彬,高橋聡子,杉山秀太,宮本千央,吉田彩佳,小林杏,前畑洋次郎,遠山歳三,吉野文彦,浜田信城,高橋俊介,李昌一
  • Journal Title: 第12回AOB研究会プロシーディング―抗酸化に期待すること Pages: 29-32
  • Peer Reviewed
• [Journal Article] 脳卒中易発症性高血圧自然発症ラット（SHRSP）に対するAOBの効果 (2013)
  • Author(s): 徳富文彬，高橋聡子，杉山秀太，宮本千央，吉田彩佳，小林 杏，前畑洋次郎，遠山歳三，吉野文彦，浜田信城，高橋俊介，李 昌一
  • Journal Title: AOB研究会プロシーディング―抗酸化に期待すること Volume: 12 Pages: 29-32
• [Journal Article] Stress and chewing affect blood flow and oxygen levels in the rat brain. (2012)
  • Author(s): Miyake S., Wada-Takahashi S., Honda H., Takahashi SS., Sasaguri K., Sato S., Lee M-C.
  • Journal Title: Archives of Oral Biology Volume: 57(11) Issue: 11 Pages: 1491-1497
  • DOI: 10.1016/j.archoralbio.2012.06.008
  • Peer Reviewed
• [Journal Article] Fasudil Suppresses Fibrosarcoma Growth by Stimulating Secretion of the Chemokine CXCL14/BRAK (2012)
  • Author(s): Miyamoto C, Maehata Y, Ozawa S., Ikoma T, Kubota E, Izukuri K, Kato Y, Hata R, Lee M-C
  • Journal Title: Journal of Pharmacological Sciences Volume: 120 Issue: 3 Pages: 241-249
  • DOI: 10.1254/jphs.12177FP
  • NAID: 10031147570
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region (2012)
  • Author(s): Ikoma T, Ozawa S, Suzuki K, Kondo T, Maehata Y, Lee MC, Hata R, Kubota E
  • Journal Title: Biochemical and biophysical Research Communications Volume: 420(2) Issue: 2 Pages: 217-22
  • DOI: 10.1016/j.bbrc.2012.01.157
  • Peer Reviewed
• [Journal Article] Dental resin curing blue light induced oxidative stress with reactive oxygen species production (2012)
  • Author(s): Yoshino F, Yoshida A, Okada E, Okada Y, Maehata Y, Miyamoto C, Kishimoto S, Otsuka T, Nishimura T, Lee M-C
  • Journal Title: Journal of Photochemistry and Photobiology B : Biology Volume: 114 Pages: 73-78
  • DOI: 10.1016/j.jphotobiol.2012.05.012
  • Peer Reviewed
• [Journal Article] Inhibitory effects of Jixueteng on P. gingivalis-induced bone loss and osteoclast differentiation (2012)
  • Author(s): Toyama T, Todoki K, Takahashi Y, Watanabe K, Takahashi S-S, Sugiyama S, Lee M-C, Hamada N
  • Journal Title: Archives of Oral Biology Volume: 57(11) Issue: 11 Pages: 1529-1536
  • DOI: 10.1016/j.archoralbio.2012.05.011
• [Journal Article] Gingival vascular functions are altered in type 2 diabetes mellitus model and/or periodontitis model (2012)
  • Author(s): Sugiyama S., Takahashi S-S., Tokutomi F., Yoshida A., Kobayashi K., Yoshino F., Wada-Takahashi S., Toyama T., Watanabe K.,Hamada N., Todoki K., Lee M-C.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 2 Pages: 108-113
  • DOI: 10.3164/jcbn.11-103
  • NAID: 130004879293
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] ESR investigation of ROS generated by H<Sub>2</Sub>O<Sub>2</Sub> bleaching with TiO<Sub>2</Sub> coated HAp (2012)
  • Author(s): Saita M, Kobayashi K, Yoshino F, Hase H, Nonami T, Kimoto K, Lee M-C
  • Journal Title: Dental Materials Journal Volume: 31 Issue: 3 Pages: 458-464
  • DOI: 10.4012/dmj.2011-192
  • NAID: 10030315444
  • ISSN: 0287-4547, 1881-1361
  • Peer Reviewed
• [Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy (2012)
  • Author(s): Yoshino F, Yoshida A, Wada-Takahashi S, Sugiyama S, Tokutomi F, Maehata Y, Miyamoto C, Komatsu T, Takahashi S-S, Kobayashi K, Lee M-C
  • Journal Title: Archives of Oral Biology Volume: 57 (6) Pages: 654-662
  • Peer Reviewed
• [Journal Article] 歯周病原細菌感染による歯肉循環変化/脳卒中易発症性高血圧自然発症ラット(SHRSP)を用いた解析 (2012)
  • Author(s): 高橋聡子,徳富文彬,杉山秀太,宮本千央,吉田彩佳,小林杏,前畑洋次郎,熊田秀文,吉野文彦,浜田信城,高橋俊介,李昌一
  • Journal Title: 第11回AOB研究会プロシーディング-酸化ストレス症候群に克つ- Pages: 33-36
• [Journal Article] Oral characteristics of a patient with Ekman-Westborg-Julin trait : a case history (2012)
  • Author(s): Komatsu T, Kurihara T, Ito Y, Lee M-C, Miyagi A, Ikeda M
  • Journal Title: Special Care Dentistry Volume: 32 (2) Pages: 70-74
  • Peer Reviewed
• [Journal Article] Soft-food diet induces oxidative stress in the rat brain (2012)
  • Author(s): Ohno A, Yoshino F, Yoshida A, Hori N, Ono Y, Kimoto K, Onozuka M, Lee M-C
  • Journal Title: Neuroscience Letters Volume: 508 (1) Issue: 1 Pages: 42-46
  • DOI: 10.1016/j.neulet.2011.12.015
  • Peer Reviewed
• [Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy. (2012)
  • Author(s): Yoshino F., Yoshida A., Wada-Takahashi S., Sugiyama S., Tokutomi F., Maehata Y., Miyamoto C., Komatsu T., Takahashi S-S., Kobayashi K., Lee M-C.
  • Journal Title: Archives of Oral Biology Volume: 57 (6) Issue: 6 Pages: 654-662
  • DOI: 10.1016/j.archoralbio.2011.12.009
  • Peer Reviewed
• [Journal Article] 歯周病原細菌感染による歯肉循環変化/脳卒中易発症性高血圧自然発症ラット（SHRSP）を用いた解析 (2012)
  • Author(s): 高橋聡子，徳富文彬，杉山秀太，宮本千央，吉田彩佳，小林 杏，前畑洋次郎，熊田秀文，吉野文彦，浜田信城，高橋俊介，李 昌一
  • Journal Title: AOB研究会－酸化ストレス症候群に克つ－ Volume: 11 Pages: 34-37
• [Journal Article] Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain (2011)
  • Author(s): Yoshino F, Yoshida A., Umigai N., Kubo K., Lee M-C.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 3 Pages: 182-187
  • DOI: 10.3164/jcbn.11-01
  • NAID: 130004466653
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects (2011)
  • Author(s): Yoshino F, Yoshida A, Sugiyama S, Tokutomi F, Miyamoto C, Maehata Y, Kobayashi K, Wada-Takahashi S, Maetani T, Okada E, Okada Y, Komatsu T, Takahashi S-S, Wan J, Lee M-C
  • Journal Title: ANTI-AGING MEDICINE Volume: 8 Issue: 4 Pages: 48-52
  • DOI: 10.3793/jaam.8.48
  • NAID: 130000968342
  • ISSN: 1882-2762
  • Peer Reviewed
• [Journal Article] Direct Assessment of the Antioxidant Properties of Midazolam by Electron Spin Resonance Spectroscopy (2011)
  • Author(s): Hata M., Kobayashi K., Yoshino F., Yoshida A., Sugiyama S., Miyamoto C., Tokutomi F., Maehata Y., Wada-Takahashi S., Takahashi S-S., Komatsu T., Yoshida K., Lee M-C.
  • Journal Title: Journal of Anesthesia Volume: 25 Issue: 5 Pages: 765-769
  • DOI: 10.1007/s00540-011-1184-6
  • NAID: 10031137045
  • Peer Reviewed
• [Journal Article] Direct assessment by electron spin resonance spectroscopy of the antioxidant effects of French maritime pine bark extract in the maxillofacial region of hairless mice (2011)
  • Author(s): Yoshida A., Yoshino F., Tsubata M., Ikeguchi M., Nakamura T., Lee M-C.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 2 Pages: 79-86
  • DOI: 10.3164/jcbn.10-103
  • NAID: 130004466650
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy (2011)
  • Author(s): Kobayashi K, Maehata Y, Kawamura Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Wada-Takahashi S, Komatsu T, Takahashi S-S, Lee M-C
  • Journal Title: Journal of Pharmacological Science Volume: 116 (1) Pages: 97-106
  • NAID: 10029894130
  • Peer Reviewed
• [Journal Article] Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects. (2011)
  • Author(s): Yoshino F., Yoshida A., Sugiyama S., Tokutomi F., Miyamoto C., Maehata Y., Kobayashi K., Wada-Takahashi S., Maetani T., Okada E., Okada Y., Komatsu T., Takahashi S-S., Wan J., Lee M-C
  • Journal Title: Anti-Aging Medicine Volume: 8 (4) Pages: 48-52
  • NAID: 130000968342
  • Peer Reviewed
• [Journal Article] Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. (2011)
  • Author(s): Kobayashi K., Maehata Y., Kawamura Y., Kusubata M., Hattori S., Tanaka K., Miyamoto C., Yoshino F., Yoshida A., Wada-Takahashi S., Komatsu T., Takahashi S-S., Lee M-C.
  • Journal Title: Journal of Pharmacological Science Volume: 116 (1) Pages: 97-106
  • NAID: 10029894130
  • Peer Reviewed
• [Presentation] レドックスインジェクタブルゲルによる口腔内レドックス治療へのアプローチ (2014)
  • Author(s): 李昌一,斉田牧子,金子純也,佐藤武則,高橋俊介,高橋聡子,川股亮太,櫻井孝,浜田信城,木本克彦,長崎幸夫
  • Organizer: つくば医工連携フォーラム2014
  • Place of Presentation: つくば
  • Year and Date: 2014-01-28
• [Presentation] レドックスインジェクタブルゲルによる口腔内レドックス治療の開発 (2014)
  • Author(s): 斉田牧子,金子純也,佐藤武則,高橋俊介,高橋聡子,川股亮太,櫻井孝,浜田信城,李昌一,長崎幸夫,木本克彦
  • Organizer: 第143回神奈川歯科大学学会例会
  • Place of Presentation: 横須賀
  • Year and Date: 2014-01-12
• [Presentation] 前畑洋次郎:頭頸部扁平上皮癌におけるROCK阻害剤によるCXCL14/BRAKを介した抗腫瘍効果の検討 (2014)
  • Author(s): 宮本千央,生駒丈晴,小澤重幸,高橋俊介,高橋聡子,吉野文彦,吉田彩佳,畑隆一郎,李昌一
  • Organizer: 神奈川歯科大学学会第143回例会
  • Place of Presentation: 横須賀
  • Year and Date: 2014-01-09
• [Presentation] 光機能化処理におけるインプラント周囲炎への抑制効果について (2013)
  • Author(s): 石井康鉉,松尾雅斗,星憲幸,木本克彦,高橋俊介,高橋聡子,川股亮太,櫻井孝
  • Organizer: 神奈川歯科大学学会第48回総会
  • Place of Presentation: 横須賀
  • Year and Date: 2013-11-30
• [Presentation] 化学療法において併発する口内炎における活性酸素評価 (2013)
  • Author(s): 吉野文彦,吉田彩佳,高橋俊介,高橋聡子,前畑洋次郎,宮本千央,李昌一
  • Organizer: 神奈川歯科大学学会第48回総会
  • Place of Presentation: 横須賀
  • Year and Date: 2013-11-30
• [Presentation] 2型糖尿病による歯肉循環調整機能(血管弾性)の変化 (2013)
  • Author(s): 高橋俊介,杉山秀太,高橋聡子,吉野文彦,前畑洋次郎,宮本千央,吉田彩佳,李昌一,松尾雅斗,遠山歳三,佐藤武則,渡辺清子,浜田信城
  • Organizer: 神奈川歯科大学学会第48回総会
  • Place of Presentation: 横須賀
  • Year and Date: 2013-11-30
• [Presentation] 歯科治療に用いられる青色光照射が血管平滑筋へおよぼす影響 (2013)
  • Author(s): 吉田彩佳,吉野文彦,前畑洋次郎,宮本千央,高橋聡子,高橋俊介,李昌一
  • Organizer: 第13回AOB研究会
  • Place of Presentation: 台東区
  • Year and Date: 2013-07-12
• [Presentation] 光機能化処理インプラントにおける実験的炎症時の周囲組織変化について (2013)
  • Author(s): 高橋俊介,高橋聡子,松尾雅斗
  • Organizer: 第55回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岡山
• [Presentation] Porphyromonas gingivalis 感染による口腔内微小循環血流量の変調に対するAOB の効果 (2013)
  • Author(s): 高橋聡子,徳富文彬,杉山秀太,宮本千央,吉田彩佳,小林杏,前畑洋次郎,遠山歳三, 吉野文彦,浜田信城,高橋俊介, 李 昌一
  • Organizer: AOB研究会
  • Place of Presentation: 東京
• [Presentation] 2型糖尿病による歯肉循環調整機能（血管弾性）の変化 (2013)
  • Author(s): 高橋俊介，杉山秀太，高橋聡子，吉野文彦，前畑洋次郎，宮本千央，吉田彩佳，李 昌一，松尾雅斗，遠山歳三，佐藤武則，渡辺清子，浜田信城
  • Organizer: 神奈川歯科大学学会 第 48 回総会
  • Place of Presentation: 横須賀
• [Presentation] 光機能化処理インプラントにおける実験的炎症時の周囲組織変化について (2013)
  • Author(s): 高橋俊介，高橋聡子，松尾雅斗
  • Organizer: 第 55 回 歯科基礎医学会学術大会･総会
  • Place of Presentation: 岡山
• [Presentation] 脳卒中易発症性高血圧自然発症ラット(SHRSP)に対するAOBの効果 (2012)
  • Author(s): 徳富文彬,高橋聡子,杉山秀太,宮本千央,吉田彩佳,小林杏,前畑洋次郎,遠山歳三,吉野文彦,浜田信城,高橋俊介,李昌一
  • Organizer: 第12回AOB研究会
  • Place of Presentation: 京都
  • Year and Date: 2012-06-29
• [Presentation] Oral Vascular Functions are Altered in Periodontitis and/or Stroke Disease Model (2012)
  • Author(s): Tokutomi F, Wada-Takahashi S, Sugiyama S, Takahashi S-S, Sato T, Toyama T, Hamada N, Lee M-C
  • Organizer: 2012 FDI Annual World Dental Congress
  • Place of Presentation: Hong Kong
• [Presentation] 脳卒中易発症性高血圧自然発症ラット(SHRSP)への歯周病現細菌感染による循環調節機能変化の解析 (2012)
  • Author(s): 徳富文彰,高橋聡子,宮本千央,遠山歳三,杉山秀太,吉田彩佳,小林杏,前畑洋次郎,吉野文彦,高橋俊介,浜田信城,李昌一
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜市
• [Presentation] Assessment of Salivary Antioxidant Activity Involved in Periodontitis. (2012)
  • Author(s): Yoshino F., Yoshida A., Wada-Takahashi S., Tokutomi F., Lee M-C.
  • Organizer: 2012 FDI Annual World Dental Congress
  • Place of Presentation: Hong Kong
• [Presentation] ral Vascular Functions are Altered in Periodontitis and/or Stroke Disease Model. (2012)
  • Author(s): okutomi F., Wada-Takahashi S., Sugiyama S., TakahashiS.-S., Sato T., Toyama T., Hamada N., Lee M-C.
  • Organizer: 2012 FDI Annual World Dental Congress
  • Place of Presentation: Hong Kong
• [Presentation] 頭頸部扁平上皮癌細胞において酸化ストレスは腫瘍抑制性ケモカインBRAK/CXCL14の発現を抑制する． (2012)
  • Author(s): 前畑洋次郎, 宮本千央, 吉野文彦, 加藤靖正, 吉田彩佳, 高橋聡子, 高橋俊介, 畑 隆一郎, 李昌一
  • Organizer: 第 54回歯科基礎医学会学術大会
  • Place of Presentation: 郡山
• [Presentation] 脳卒中易発症性高血圧自然発症ラット(SHRSP)に対するAOBの効果 (2012)
  • Author(s): 徳富文彬，高橋聡子，杉山秀太，宮本千央，吉田彩佳，小林 杏，前畑洋次郎，遠山歳三，吉野文彦，浜田信城，高橋俊介，李 昌一
  • Organizer: 第12 回 AOB 研究会
  • Place of Presentation: 京都
• [Presentation] 血管平滑筋に対する歯科用レジン照射器の青色光照射がおよぼす影響 (2012)
  • Author(s): 吉田彩佳，吉野文彦，前畑洋次郎，高橋俊介，高橋聡子，宮本千央，徳富文彬，杉山秀太，李 昌一
  • Organizer: 第12 回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] 脳卒中易発症性高血圧自然発症ラット (SHRSP) への歯周病現細菌感染による循環調節機能変化の解析 (2012)
  • Author(s): 徳富文彰，高橋聡子，宮本千央，遠山歳三，杉山秀太，吉田彩佳，小林 杏，前畑洋次郎，吉野文彦，高橋俊介，浜田信城，李 昌一
  • Organizer: 第12 回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] 唾液抗酸化能を用いた客観的歯周病評価法の検討 (2012)
  • Author(s): 吉野 文彦，吉田 彩佳，高橋 聡子，徳富 文彬，李 昌一
  • Organizer: 第 65 回 酸化ストレス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] 微小循環からみた糖尿病と歯周疾患 (2011)
  • Author(s): 松尾雅斗,高橋俊介,杉山秀太,高橋聡子,李昌一,浜田信城
  • Organizer: 神奈川歯科大学学会.神奈川歯科大学学会第46回総会
  • Place of Presentation: 横須賀
  • Year and Date: 2011-12-03
• [Presentation] 生薬「鶏血藤のP. gingivalisにより誘導される骨吸収に対する抑制効果 (2011)
  • Author(s): 遠山歳三,塗々木和男,渡辺靖子,高橋俊介,杉山秀太,熊田秀文,石川恵里子,李昌一,浜田信城
  • Organizer: 神奈川歯科大学学会第46回総会
  • Place of Presentation: 横須賀
  • Year and Date: 2011-12-03
• [Presentation] 脳卒中易発症性高血圧自然発症ラット(SHRSP)における歯周病感染による口腔内循環変化の解析 (2011)
  • Author(s): 高橋聡子,徳富文彬,杉山秀太,遠山歳三,小林杏,浜田信城,高橋俊介,李昌一
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 虻田郡
  • Year and Date: 2011-07-02
• [Presentation] 歯周病感染による歯肉循環変化/脳卒中易発症性高血圧自然発症ラット(SHRSP)を用いた解析 (2011)
  • Author(s): 高橋聡子,徳富文彬,杉山秀太,宮本千央,吉田彩佳,小林杏,前畑洋次郎,熊田秀文,吉野文彦,浜田信城,高橋俊介,李昌一
  • Organizer: 第11回AOB研究会
  • Place of Presentation: 虻田郡
  • Year and Date: 2011-07-01
• [Presentation] 歯周病感染による歯肉循環変化/脳卒中易発症性高血圧自然発症ラット (SHRSP) を用いた解析 (2011)
  • Author(s): 高橋聡子，徳富文彬，杉山秀太,宮本千央, 吉田彩佳，小林 杏，前畑洋次郎，熊田秀文, 吉野文彦，浜田信城，高橋俊介，李 昌一
  • Organizer: 第 11 回 AOB 研究会
  • Place of Presentation: 北海道,虻田郡
• [Presentation] 脳卒中易発症性高血圧自然発症ラット (SHRSP) における歯周病感染による口腔内循環変化の解析 (2011)
  • Author(s): 高橋聡子，徳富文彬，杉山秀太，遠山歳三，小林 杏，浜田信城，高橋俊介，李 昌一
  • Organizer: 第 64 回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道, 虻田郡