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The onset diagnosis of the arteriosclerosis by periodontitis through the serum amyloid A.

Research Project

Project/Area Number 23593074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

YOSHINARI Nobuo  松本歯科大学, 歯学部, 教授 (20231699)

Co-Investigator(Kenkyū-buntansha) TAGUCHI Akira  松本歯科大学, 歯学部, 教授 (70243582)
NISHIDA Eisaku  愛知学院大学, 歯学部, 非常勤講師 (10512519)
MUTO Akinori  松本歯科大学, 歯学部, 講師 (50549433)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周病 / 血清アミロイドA / 動脈硬化症 / Periodontal Medicine / Cardiovascular disease / Periodontal disease / Serum Amyloid A / Interleukin-6
Research Abstract

The purpose of this study was to elucidate the onset mechanism of atherosclerosis through periodontal disease induced serum amyloid A (SAA). Both of the serum SAA protein level and the aortic lipid deposition were increased significantly in the periodontitis model mouse which injected IL-6 into periodontal tissue. And the mRNA expressions of monocyte adhesion, migration factors and the SAA-receptor TLR2 were up-regulated significantly with SAA treatment for the endothelial cells. Furthermore, the expression of TLR2 was observed at the initial disease area of the aorta immunohistochemically in the mouse model.
Therefore, these results suggest that periodontal disease induced SAA could deteriorate the atherosclerosis through TLR2, and a possibility that the onset diagnosis of arteriosclerosis could be performed according to the severity of the periodontal disease.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (37 results)

All 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results,  Open Access: 1 results) Presentation (17 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] Osteoprotegrin-deficient male mice as a model for severe alveolarbone loss : Ccmparison with RANKL-overexpressing transgenic mice2013

    • Author(s)
      Koide M, Kobayashi Y, Ninomiya T, Nakamura M, Yasuda H, Arai Y, Okahashi N, Yoshinari N, Takahashi N, Udagawa N
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 773-782

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between oral health and the risk of lacunar infarction in Japanese adults.2013

    • Author(s)
      Taguchi A, Miki M, Muto A, Kubokawa K, Migita K, Higashi Y, Yoshinari N.
    • Journal Title

      Gerontology

      Volume: 59 Issue: 6 Pages: 499-506

    • DOI

      10.1159/000353707

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: Comparison with RANKL-overexpressing transgenic male mice.2013

    • Author(s)
      Koide M et al.
    • Journal Title

      Endocrinology

      Volume: 190 Issue: 2 Pages: 773-782

    • DOI

      10.1210/en.2012-1928

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 治療抵抗性歯周炎患者のアジスロマイシン投与における臨床的,細菌学的評価2013

    • Author(s)
      佐藤哲夫,藤波義明,平岡行博,荒 敏昭,窪川恵太,海瀬聖仁,武藤昭紀,三木 学,岩井由紀子,王 宝禮,吉成伸夫
    • Journal Title

      日本歯科存学会誌

      Volume: 56 Pages: 239-251

    • NAID

      110009674434

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoprotegrin-Deficient Male Mice as a Model for Severe AlveolarBone Loss: Comparison With RANKL - Overexpressing Transgenic Mice.2013

    • Author(s)
      Masanori Koide, Yasuhiro Kobayashi, Tadashi Ninomiya, Midori Nakamura, Hisataka Yasuda, Yoshinori Arai, Nobuo Okahashi, Nobuo Yoshinari, Naoyuki Takahashi, Nobuyuki Udagawa
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 773-782

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 上顎洞底が近接した部位における歯の自家移植症例2013

    • Author(s)
      武藤昭紀,窪川恵太,海瀬聖仁,三木 学,内山真紀子,内田啓一,山本昭夫,田口 明,吉成伸夫
    • Journal Title

      日本歯科保存学雑誌(投稿中)

      Volume: 56

    • NAID

      110009674435

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tetracyclines convert the osteoclastic- differentiation pathway of progenitor cells to produce dendritic cell-like cells2012

    • Author(s)
      Kinugawa S, Koide M, Kobayashi Y, Mizoguchi T, Ninomiya T, Muto A, Kawahawa I, Nakamura M, Yasuda H, Takahashi N, Udagawa N
    • Journal Title

      J Immunol

      Volume: 188 Pages: 1772-1781

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 松本歯科大学病院来院患者の歯科実態調査. -パノラマエックス線写真による現在歯数についての検討-2012

    • Author(s)
      山田真一郎,内田啓一,田口 明,三木 学,吉成伸夫,窪川恵太,西田英作
    • Journal Title

      日本歯科保存学雑誌

      Volume: 55 Pages: 46-52

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯肉メラニン色素沈着症に対する歯科用(Er:YAG, CO2)レーザーの着色除去効果2012

    • Author(s)
      西田英作,三木 学,武藤昭紀,窪川恵太,片瀬剛士,内田啓一,阪中孝一郎,大原盛勝,大野友三,吉成伸夫
    • Journal Title

      日本レーザー歯学会誌

      Volume: 23 Pages: 27-32

    • NAID

      130004565020

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The short-term effects of various oral care methods in dependent elderly: comparison between toothbrushing, tongue cleaning with sponge brush and wiping on oral mucous membrane by chlorhexidine.2012

    • Author(s)
      Kazuhisa Tashiro, Tamiko Katoh, Nobuo Yoshinari, Kaname Hirai, Nobuyuki Andoh, Kakuma Makii, Kouichiro Matsuo, Tadashi Ogasawara
    • Journal Title

      Gerodontology

      Volume: 29

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 第7回(平成23年度)リリー研究助成成果報告 口腔衛生指標によるFRAX®の10年間骨折リスクの推定に関する検討2012

    • Author(s)
      田口 明,三木 学,高橋美穂,西田英作,武藤昭紀,細井孝之,吉成伸夫
    • Journal Title

      Osteoporosis Japan

      Volume: 20 Pages: 470-473

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 上顎前歯部インプラント埋入後に歯肉退縮を起こした1症例2012

    • Author(s)
      高橋美穂,上松隆司,堂東亮輔,杉野紀幸,吉成伸夫
    • Journal Title

      松本歯学

      Volume: 24 Pages: 131-139

    • NAID

      120005273803

    • Related Report
      2012 Research-status Report
  • [Journal Article] 歯周基本治療により改善が見られたカルシウム拮抗剤誘発性歯肉増殖症の2症例2012

    • Author(s)
      武藤昭紀,窪川恵太,海瀬聖仁,三木 学,内山真紀子,内田啓一,山本昭夫,田口 明,吉成伸夫
    • Journal Title

      日本歯周病学会会誌

      Volume: 55 Pages: 43-53

    • NAID

      10031163446

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011

    • Author(s)
      Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 26 Issue: 12 Pages: 2978-2990

    • DOI

      10.1002/jbmr.490

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia : A comparison of atherosclerotic peripheral arterial disease and buerger disease2011

    • Author(s)
      Taguchi A(16人中13番目), Higashi Y(16人中16番目)
    • Journal Title

      Circ Cardiovasc Interv

      Volume: 4 Issue: 1 Pages: 15-25

    • DOI

      10.1161/circinterventions.110.955724

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 動脈硬化易形成性マウスにおける加齢の影響特定2013

    • Author(s)
      海瀬聖仁,武藤昭紀,窪川恵太,三木学,岩井由紀子,石岡康明,吉成伸夫
    • Organizer
      第139回日本歯科保存学会
    • Place of Presentation
      秋田
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of SAA on atherosclerogenesis in ApoE deficient mice2013

    • Author(s)
      Muto A, Takahashi K, Kaise K, Kubokawa K, Miki M, Taguchi A, Yoshinari N
    • Organizer
      10th Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      Nara
    • Year and Date
      2013-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of serum amyloid A (SAA) accelerates atherosclerosis in mice2012

    • Author(s)
      Yoshinari N, MUTO A, Kubokawa K, Kaise K, Takahashi K, Miki M, Taguch A
    • Organizer
      The 51st Annual Scientific Meeting of the Korean Academy of Periodontology
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Serum amyloid Aを介した歯周病から動脈硬化症への経路2012

    • Author(s)
      窪川恵太,武藤昭紀,海瀬聖仁,三木学,高橋弘太郎,坂本浩,吉成伸夫
    • Organizer
      第22回日本歯科医学学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 培養ヒト血管内皮細胞に対する歯周病由来Serum Amyloid Aの効果2012

    • Author(s)
      海瀬聖仁,武藤昭紀,髙橋弘太郎,窪川恵太,髙橋美穂,西田英作,河谷和彦,吉成伸夫
    • Organizer
      第22回日本歯科医学学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病由来動脈硬化病変部における接着関連因子の発現2012

    • Author(s)
      高橋弘太郎,窪川恵太,武藤昭紀,海瀬聖仁,山田真一郎,上条博之,中野敬介,川上敏行,吉成伸夫
    • Organizer
      第22回日本歯科医学学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Circulating lineage-committed osteoclast precursors settle down into bone in mice2012

    • Author(s)
      Muto A, Mizoguchi T, Udagawa T, Josef M. Penninger, Takahashi N, Yoshinari N
    • Organizer
      98^<th> Annual Meeting American Academy of Periodontology
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2012-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 急性反応性タンパク血清アミロイドAを介した歯周病による動脈硬化症発症の検討2011

    • Author(s)
      窪川恵太,中野敬介,西田英作,武藤昭紀,吉成伸夫,川上敏行
    • Organizer
      2011年度推進研究費研究報告会
    • Place of Presentation
      松本歯科大学(塩尻市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 血管内皮細胞を用いたアテローム性動脈硬化発症におけるSAAの機能解析2011

    • Author(s)
      西田英作, 上松隆司, 窪川恵太, 高橋美穂, 吉成伸夫
    • Organizer
      2011年度推進研究費研究報告会
    • Place of Presentation
      松本歯科大学(塩尻市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 血清アミロイドAによる動脈硬化症発症の検討2011

    • Author(s)
      窪川恵太,海瀬聖仁,西田英作,武藤昭紀,田口 明,吉成伸夫
    • Organizer
      第135回秋季日本歯科保存学会
    • Place of Presentation
      大阪国際交流センター(大阪市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 培養ヒト血管内皮細胞に対する血清アミロイドA(SAA)の効果2011

    • Author(s)
      西田英作, 窪 恵太, 高橋弘太郎, 海瀬聖仁, 武藤昭紀, 高橋美穂, 吉成伸夫
    • Organizer
      第6回日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
    • Place of Presentation
      朝日大学歯学部(岐阜県瑞穂市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 急性反応性タンパク血清アミロイドAを介した歯周病による動脈硬化症発症の検討各種メラニン色素除去法の比較2011

    • Author(s)
      窪川恵太,西田英作,武藤昭紀,海瀬聖仁,高橋弘太郎,吉成伸夫
    • Organizer
      第6回日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
    • Place of Presentation
      朝日大学歯学部(岐阜県瑞穂市)
    • Related Report
      2011 Research-status Report
  • [Presentation] The effect of SAA on atherosclerogenesis in ApoE deficient mice

    • Author(s)
      Muto A, Takahashi K, Kaise K, Kubokawa K, Miki M, Taguchi A, Yoshinari N
    • Organizer
      10th Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2013 Annual Research Report
  • [Presentation] 動脈硬化易形成性マウスにおける加齢の影響特定

    • Author(s)
      海瀬聖仁,武藤昭紀,窪川恵太,三木 学,岩井由紀子,石岡康明,吉成伸夫
    • Organizer
      第139回日本歯科保存学会
    • Place of Presentation
      秋田県アトリウム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周病と全身の関係

    • Author(s)
      吉成伸夫
    • Organizer
      第7回信州公衆衛生学会総会教育講演
    • Place of Presentation
      松本歯科大学601教室(塩尻市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The effect of SAA on atherosclerosis in ApoE deficient mice.

    • Author(s)
      Nobuo Yoshinari
    • Organizer
      98th Annual Meeting American Academy of Periodontology in collaboration with theJapanese Society of Periodontology
    • Place of Presentation
      Los Angeles Convention Center(USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] パノラマX線写真によるラクナ梗塞のスクリーニング

    • Author(s)
      田口 明
    • Organizer
      NPO法人日本歯科放射線学会第53回学術大会・第9回定期総会
    • Place of Presentation
      いわて県民情報交流センター(盛岡市)
    • Related Report
      2012 Research-status Report
  • [Book] 臨床歯周病学第2版,吉江弘正,伊藤公一,村上伸也,申基喆編,第2編ベーシック編-基礎知識-第19章,歯周病のリスクファクター2013

    • Author(s)
      武藤昭紀,吉成伸夫
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 臨床歯周病学 第2版2013

    • Author(s)
      武藤昭紀,吉成伸夫
    • Total Pages
      396
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2012 Research-status Report
  • [Book] 新・口腔の生理からどうして?を解く森本俊文監修第25章「どうして歯石のような硬いものができるのだろう?」104-107,第27章「どうしてカリエスリスクに遺伝性は認められず歯周病リスクにはみとめられるのだろう?」2012

    • Author(s)
      武藤昭紀,西田英作,吉成伸夫
    • Publisher
      デンタルダイヤモンド社
    • Related Report
      2013 Final Research Report
  • [Book] 新・口腔の生理から?(どうして)を解く2012

    • Author(s)
      高橋美穂,西田英作,武藤昭紀,吉成伸夫
    • Total Pages
      141
    • Publisher
      Ddデンタルダイヤモンド社
    • Related Report
      2012 Research-status Report
  • [Book] 今日の治療指針 私はこうして治療している2012 Volume 54 歯周病(歯肉炎,歯周炎)2012

    • Author(s)
      吉成伸夫
    • Total Pages
      1955
    • Publisher
      株式会社医学書院
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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