| Project/Area Number |
23593075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Toshiyuki 松本歯科大学, 総合歯科医学研究所, 教授 (80104892)
TSUJIGIWA Hidetugu 岡山大学, 医歯(薬)学総合研究科, 准教授 (70335628)
TOMIDA Mihoko 松本歯科大学, 歯学部, 准教授 (00366329)
MURAOKA Rina 松本歯科大学, 歯学部, 助教 (20549430)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨髄幹細胞 / 組織修復 / リモデリング / 分子調節機構 / 骨髄細胞 / 細胞分化 / 歯周組織 / メカニカルストレス / 歯科矯正学 / 歯科矯正治療 |
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| Research Abstract |
We demonstrated the following results in this study.
1) Bone marrow stem cells have a potential to differentiate into dental pulp cells and periodontal ligament cells. 2) Bone marrow stem cells engraft in the active remodeling tissues. 3) The expression of Runx2, Msx2, ALP, Neuroendocrine-related factors and HSPs were enhanced in the periodontal ligament under injurious stimuli. 4) These results can be applied to development of new orthodontic treatment and the effective treatment of the injury.
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