Elucidation of the molecular mechanisms of tissue repair using stem cells

• Project/Area Number: 23593075
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: NAKANO Keisuke 松本歯科大学, 歯学部, 准教授 (10325095)
• Co-Investigator(Kenkyū-buntansha): KAWAKAMI Toshiyuki 松本歯科大学, 総合歯科医学研究所, 教授 (80104892) ; TSUJIGIWA Hidetugu 岡山大学, 医歯(薬)学総合研究科, 准教授 (70335628) ; TOMIDA Mihoko 松本歯科大学, 歯学部, 准教授 (00366329) ; MURAOKA Rina 松本歯科大学, 歯学部, 助教 (20549430)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨髄幹細胞 / 組織修復 / リモデリング / 分子調節機構 / 骨髄細胞 / 細胞分化 / 歯周組織 / メカニカルストレス / 歯科矯正学 / 歯科矯正治療

Research Abstract

We demonstrated the following results in this study.
1) Bone marrow stem cells have a potential to differentiate into dental pulp cells and periodontal ligament cells. 2) Bone marrow stem cells engraft in the active remodeling tissues. 3) The expression of Runx2, Msx2, ALP, Neuroendocrine-related factors and HSPs were enhanced in the periodontal ligament under injurious stimuli. 4) These results can be applied to development of new orthodontic treatment and the effective treatment of the injury.

Research Products

• [Journal Article] Expression of TRAF6 Protein and TRAF6 mRNA during Different Stages of Deciduous Tooth Root Physiological Absorption (2013)
  • Author(s): Zhang Gg, Zhou L, Ito K, Sugita Y, Nakano K, Maeda H, Wang X and Wang M
  • Journal Title: Journal of Hard Tissue Biology Volume: 22 Issue: 1 Pages: 1-6
  • DOI: 10.2485/jhtb.22.1
  • NAID: 130004848397
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] HSP70 Expression in the Mouse Dental Pulp after Immediate Teeth Separation (2013)
  • Author(s): Nakano K, Saito S, Nabeyama A, Oishi S, Sato M, Yokoi Y, Osuga N, Okafuji N and Kawakami T
  • Journal Title: Journal of Hard Tissue Biology Volume: 22 Issue: 1 Pages: 7-12
  • DOI: 10.2485/jhtb.22.7
  • NAID: 130004848413
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Promotion of Transplanted Bone Marrow-derived Cell Migration into the Periodontal Tissues due to Orthodontic Mechanical Stress (2013)
  • Author(s): Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nakamura T, Okafuji N, Nagatsuka H, Kawakami T
  • Journal Title: Int J Med Sci Volume: 10(10) Issue: 10 Pages: 1321-1326
  • DOI: 10.7150/ijms.6631
  • Peer Reviewed
• [Journal Article] Establishment of Experimental Periapical Inflammatory Lesions in Mice (2013)
  • Author(s): Osuga N, Matsuda S, Shoumura M, Moriyama K, Yokoi Y, Nakano K and Kawakami T
  • Journal Title: Journal of Hard Tissue Biology Volume: 22 Issue: 4 Pages: 517-520
  • DOI: 10.2485/jhtb.22.517
  • NAID: 130004480626
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Heat shock protein27 expression and cell differentiation in ameloblastomas (2013)
  • Author(s): Fujita M, Nakano K, Funato A, Sugita Y, Kubo K, Maeda H, Okafuji N, Hasegawa H and Kawakami T
  • Journal Title: Int J Med Sci Volume: 10 Issue: 10 Pages: 1271-1277
  • DOI: 10.7150/ijms.6597
  • Peer Reviewed
• [Journal Article] Immunohistochemical Changes of Heat Shock Protein 27 Expression in the Mouse Periodontal Tissues Exposed to Orthodontic Mechanical Stress (2012)
  • Author(s): Tomoda M, Nakano K, Muraoka R, Matsuda H, Yamada K and Kawakami T
  • Journal Title: Journal of Hard Tissue Biology Volume: 21 Issue: 1 Pages: 43-50
  • DOI: 10.2485/jhtb.21.43
  • NAID: 130004480532
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] The Value of 3-Dimensional Computed Tomography for Jaws Osteotomies (2012)
  • Author(s): Yan G, Sugita Y, Wang X, Takayama M, Jinno M, Nakano K, Kawakami T, Yang M and Lu L
  • Journal Title: Journal of Hard Tissue Biology Volume: 21 Issue: 2 Pages: 97-102
  • DOI: 10.2485/jhtb.21.97
  • NAID: 130004480555
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Immunohistochemical Expression of Osterix Appearing in the Mouse Orthodontic Periodontal Tension Sides (2012)
  • Author(s): Harada T, Nakano K, Matsuda H, Muraoka R, Tomoda M, Yokoi Y, Yamada K and Okafuji N
  • Journal Title: Journal of Hard Tissue Biology Volume: 21 Issue: 3 Pages: 321-328
  • DOI: 10.2485/jhtb.21.321
  • NAID: 130004480569
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use (2011)
  • Author(s): Tomida M, Nakano K, Matsuura S and Kawakami T
  • Journal Title: Eur J Med Res Volume: 16 Issue: 6 Pages: 249-52
  • DOI: 10.1186/2047-783x-16-6-249
  • Peer Reviewed
• [Journal Article] Immunohistochemical localization of Notch signaling molecules in ameloblastomas (2011)
  • Author(s): Muraki E, Nakano K, Maeda H, Takayama M, Jinno M, Kubo K, Yoshida W, Hasegawa H and Kawakami T
  • Journal Title: Eur J Med Res Volume: 16 Issue: 6 Pages: 253-7
  • DOI: 10.1186/2047-783x-16-6-253
  • Peer Reviewed
• [Journal Article] L929 Cell Adhesion on the Surface Oxidized NiTi Shape Memory Alloy (2011)
  • Author(s): Na Y, Wang Q, Nakano K, Tomida M, Kawakami T and Zhang Y
  • Journal Title: Journal of Hard Tissue Biology Volume: 20 Issue: 1 Pages: 53-58
  • DOI: 10.2485/jhtb.20.53
  • NAID: 130004848364
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Histopathological examination of newly-developed adhesive silicone denture relining material (2011)
  • Author(s): Tomida M, Nakano K, Sato M, Matsuura S and Kawakami T
  • Journal Title: Eur J Med Res Volume: 16 Issue: 7 Pages: 328-30
  • DOI: 10.1186/2047-783x-16-7-328
  • Peer Reviewed
• [Journal Article] Transplanted Bone Marrow derived Cells Differentiated toTooth, Bone and Connective Tissues in Mice (2011)
  • Author(s): Tsujigiwa H, Katase N, Sathi GA, Buery RR, Hirata Y, Kubota M, Nakano K, Kawakami T and Nagatsuka H
  • Journal Title: Journal of Hard Tissue Biology Volume: 20 Issue: 2 Pages: 147-152
  • DOI: 10.2485/jhtb.20.147
  • NAID: 130004480521
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Immunohistochemical expression of heat shock protein27 in the mouse dental pulp after immediate teeth separation. (2011)
  • Author(s): Saito S, Nakano K, Nabeyama A, Sato M, Okafuji N, Yamamoto A, Kasahara E and Kawakami T
  • Journal Title: Eur J Med Res Volume: 16 Issue: 11 Pages: 495-500
  • DOI: 10.1186/2047-783x-16-11-495
  • Peer Reviewed
• [Journal Article] Immunohistochemical expression of hard tissue related factors in the mouse pulp after immediate teeth separation. (2011)
  • Author(s): Nabeyama A, Nakano K, Saito S, Sato M, Okafuji N, Yamamoto A, Kasahara E and Kawakami T
  • Journal Title: Eur J Med Res Volume: 16 Issue: 11 Pages: 507-513
  • DOI: 10.1186/2047-783x-16-11-507
  • Peer Reviewed
• [Journal Article] Dental caries area of rat molar expanded by cigarette smoke exposure (2011)
  • Author(s): Fijinami Y, Nakano K, Ueda O, Ara T, Hattori T, Kawakami T and Wang PL
  • Journal Title: Caries Res Volume: 45 Pages: 561-7
  • Peer Reviewed
• [Journal Article] Histopathological safety evaluation of newly-developed MgO sealer (2011)
  • Author(s): Nakano K, Tomida M, Sato M, Matsuura S, Yamamoto A, Kasahara E and Kawakami T
  • Journal Title: Eur J Mad Res Volume: 16 Pages: 526-30
  • Peer Reviewed
• [Journal Article] Phase Transformation and Corrosion Properties of Surface Oxidized NiTi Shape Memory Alloy (2011)
  • Author(s): Wang Q, Komori A, Maeda H, Zhang D, Zhang Y, Zhao B and Kawakami T
  • Journal Title: Journal of Hard Tissue Biology Volume: 20 Issue: 3 Pages: 169-176
  • DOI: 10.2485/jhtb.20.169
  • NAID: 130004722016
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] Expression of TRAF6 mRNA on the Resorbed Surface of Deciduous Teeth Root (2011)
  • Author(s): Zhang G, Nakano K, Honda Y, Wang X, Wang M, Xu Y and Kawakami T
  • Journal Title: Journal of Hard Tissue Biology Volume: 20 Issue: 3 Pages: 177-184
  • DOI: 10.2485/jhtb.20.177
  • NAID: 130004722017
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] A Consideration on the Role of HSP70 Appearing in the Periodontal Tissues due to Experimental Orthodontic Force (2011)
  • Author(s): 村岡理奈,中野敬介 ,松田浩和,共田真紀, 岡藤範正 ,山田一尋,川上敏行
  • Journal Title: Journal of Hard Tissue Biology Volume: 20 Issue: 4 Pages: 275-282
  • DOI: 10.2485/jhtb.20.275
  • NAID: 130004848367
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Presentation] 松本市マウス歯根膜細胞に発現するHSP47の分子シャペロンとしての可能性 (2013)
  • Author(s): 村岡理奈,中野敬介,松田浩和,川上敏行,岡藤範正,山田一尋
  • Organizer: 日本矯正歯科学会大会(第72回)
  • Place of Presentation: 長野県松本文化会館(プログラム・抄録集p182)
  • Year and Date: 2013-10-08
• [Presentation] 骨治癒過程における骨髄由来細胞の関与 (2013)
  • Author(s): 河合穂高,辻極秀次,伊藤聡,中野敬介,于淞,川上敏行,長塚仁
  • Organizer: 歯科基礎医学会総会(第55回)
  • Place of Presentation: 岡山大学,岡山市(J Oral Biosci 54 (S): 120, 2013)
  • Year and Date: 2013-09-21
• [Presentation] 歯科的矯正学的メカニカルストレスが惹起するHSP27のマウス歯根膜細胞における局在変化 (2013)
  • Author(s): 村岡理奈,中野敬介,山田一尋,川上敏行
  • Organizer: 歯科基礎医学会総会(第55回)
  • Place of Presentation: 岡山大学,岡山市(J Oral Biosci 54 (S): 197, 2013)
  • Year and Date: 2013-09-21
• [Presentation] 歯科矯正学的メカニカルストレスによりマウス歯根膜に発現するHSP47の分子シャペロンとしての可能性 (2013)
  • Author(s): 村岡理奈,山田一尋,中野敬介,川上敏行
  • Organizer: 硬組織再生生物学会(第22回)
  • Place of Presentation: 鶴見大学歯学部,横浜市(抄録集p28; J Hard Tissue Biol 22: 525, 2013)
  • Year and Date: 2013-08-22
• [Presentation] 歯科矯正学的メカニカルストレスによる歯周組織改造時における細胞動態 (2013)
  • Author(s): 宮城圭子,富田美穂子,中野敬介,村岡理奈,中村貴美,岡藤範正,川上敏行
  • Organizer: 硬組織再生生物学会(第22回)
  • Place of Presentation: 鶴見大学歯学部,横浜市(抄録集p29; J Hard Tissue Biol 22: 525, 2013)
  • Year and Date: 2013-08-22
• [Presentation] マウスにおける実験的慢性根尖炎症性病巣の確立 (2013)
  • Author(s): 松田紗衣佳,正村正仁,森山敬太,大須賀直人,中野敬介,川上敏行
  • Organizer: 硬組織再生生物学会(第22回)
  • Place of Presentation: 鶴見大学歯学部,横浜市(抄録集p40; J Hard Tissue Biol 22: 528, 2013)
  • Year and Date: 2013-08-22
• [Presentation] Cytological remodeling of the perio- dontal ligament tissues due to mechanical stress (2013)
  • Author(s): Kawakami T, Tomida M, Muraoka R, Nakamura T and Nakano K
  • Organizer: The 37th International Congress of Physiolo- gical Sciences
  • Place of Presentation: バーミンガム,イギリス
  • Year and Date: 2013-07-21
• [Presentation] 外傷ストレスを負荷した歯周組織変化 (2013)
  • Author(s): 岡藤範正,中野敬介,魚住智子,山木貴子,安東信行,安東史子,中村曲正,横井由紀子,大須賀直人,西川康弘
  • Organizer: 日本外傷歯学会総会・学術大会(第13回)
  • Place of Presentation: 所沢市民文化センターミューズ,所沢市(日外傷歯誌9 (2): 39, 2013)
  • Year and Date: 2013-07-20
• [Presentation] Effect of HSP70 in the perio- dontal ligaments remodeling due to orthodontic force (2013)
  • Author(s): Muraoka R, Nakano K, Yamada K and Kawakami T
  • Organizer: 89th Congress of the European Ortho- dontic Society
  • Place of Presentation: レイキャビック,アイスランド
  • Year and Date: 2013-06-29
• [Presentation] Cell dynamism of the perio- dontal tissues remodeling elicited by orthodontic mechanical stress (2013)
  • Author(s): Kawakami T, Nakano K, Tomida M, Muraoka R and Yamada K
  • Organizer: 89th Congress of the European Ortho- dontic Society
  • Place of Presentation: レイキャビック,アイスランド
  • Year and Date: 2013-06-29
• [Presentation] 歯肉線維芽細胞におけるフェニトインとカルシウム感知受容体との関係 (2012)
  • Author(s): 服部敏己,中野敬介,川上敏行
  • Organizer: 歯科基礎医学会総会(第54回)
  • Place of Presentation: 奥羽大学,郡山市(J Oral Biosci 54 (S): 156, 2012)
  • Year and Date: 2012-09-14
• [Presentation] 歯科矯正学的牽引側歯周組織におけるRunx2とOsterixの骨形成への分化誘導 (2012)
  • Author(s): 中野敬介,川上敏行
  • Organizer: 日本臨床口腔病理学会総会(第23回)
  • Place of Presentation: 東京医科歯科大学,東京(プログラム・抄録集p118)ISBN :978-1-61122-791-8; ebook, ISBN :978-1-61209-495-3
  • Year and Date: 2012-08-29
• [Presentation] 実験的歯間分離により歯髄に発現するHSP27の免疫組織化学的検討 (2012)
  • Author(s): 斉藤進之介,中野敬介,鍋山篤史,佐藤将洋,岡藤範正,山本昭夫,笠原悦男,川上敏行
  • Organizer: 硬組織再生生物学会(第21回)
  • Place of Presentation: 愛知学院大学,名古屋市(抄録集p21,J Hard Tissue Biol 22: 155, 2012.)
  • Year and Date: 2012-08-25
• [Presentation] 歯科矯正学的牽引側歯周組織におけるOsterixの蛍光免疫染色による観察 (2012)
  • Author(s): 中野敬介,原田寿久,松田浩和,村岡理奈,共田真紀,横井由紀子,山田一尋,岡藤範正
  • Organizer: 硬組織再生生物学会(第21回)
  • Place of Presentation: 愛知学院大学,名古屋市(抄録集p22,J Hard Tissue Biol 22: 155-6, 2012.)
  • Year and Date: 2012-08-25
• [Presentation] 歯間分離によりマウス歯髄に発現するHSP70の免疫組織化学的検討 (2012)
  • Author(s): 大石真太郎,斉藤進之介,鍋山篤史,中野敬介,佐藤将洋,横井由紀子,大須賀直人,岡藤範正,川上敏行
  • Organizer: 硬組織再生生物学会(第21回)
  • Place of Presentation: 愛知学院大学,名古屋市(抄録集p30,J Hard Tissue Biol 22: 158, 2012.)
  • Year and Date: 2012-08-25
• [Presentation] メカニカルストレスによりマウス歯髄組織に惹起されるChromogranin A (2012)
  • Author(s): 佐藤将洋,中野敬介,斉藤進之介,鍋山篤史,岡藤範正,山本昭夫,笠原悦男,長谷川博雅,川上敏行
  • Organizer: 硬組織再生生物学会(第21回)
  • Place of Presentation: 愛知学院大学,名古屋市(抄録集p31,J Hard Tissue Biol 22: 158, 2012.)
  • Year and Date: 2012-08-25
• [Presentation] エナメル上皮腫におけるSynaptophysinの局在 (2012)
  • Author(s): 落合隆永,中野敬介,川上敏行,長谷川博雅
  • Organizer: 硬組織再生生物学会(第21回)
  • Place of Presentation: 愛知学院大学,名古屋市(抄録集p33,J Hard Tissue Biol 22: 158-9, 2012
  • Year and Date: 2012-08-25
• [Presentation] Transplanted bone marrow derived cell migration into periodontal tissues induced by orthodontic mechanical stress (2012)
  • Author(s): Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nagatsuka H and Kawakami T
  • Organizer: International Congress of the Transplanta- tion Society (24th)
  • Place of Presentation: ベルリン,ドイツ(Abstract book p101)
  • Year and Date: 2012-07-15
• [Presentation] Migration of the transplanted bone marrow- derived cells into periodontal ligaments due to orthodontic mechanical stress (2012)
  • Author(s): Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nakamura T, Asanuma N, Nagatsuka H and Kawakami T
  • Organizer: Physiology 2012
  • Place of Presentation: エジンバラ,イギリス(Abstract book p135)
  • Year and Date: 2012-07-02
• [Presentation] Migration and differentiation of trans- planted bone marrow-derived cells into periodontal tissues promoted by mecha- nical stress (2012)
  • Author(s): Kawakami T, Tsujigiwa H, Nakano K, Tomida M, Muraoka R and Nagatsuka H
  • Organizer: Congress of the European Hematology Asso- ciation (17th)
  • Place of Presentation: アムステルダム,オランダ(Hematologica 97(s1): 729, 2012)
  • Year and Date: 2012-06-14
• [Presentation] Transplanted bone marrow-derived cell migration into periodontal tissues induced by orthodontic mechanical stress (2012)
  • Author(s): Tomida M
  • Organizer: International Congress of The Transplantation Society (24th)
  • Place of Presentation: Berlin, Germany
• [Presentation] 実験的歯間分離によりマウス歯髄に発現する硬組織関連因子 (2011)
  • Author(s): 鍋山篤史，他
  • Organizer: 硬組織再生生物学会総会（第20回）
  • Place of Presentation: 日本大学歯学部（東京都）
• [Presentation] メカニカルストレスが引き起こすマスス歯根膜組織におけるHSP27の発現変化 (2011)
  • Author(s): 村岡理奈，他
  • Organizer: 硬組織再生生物学会総会（第20回）
  • Place of Presentation: 日本大学歯学部（東京都）
• [Presentation] Promoting effect of mechanical stress to transplanted bone marrow-derived cell migration into periodontal tissues (2011)
  • Author(s): Tomida M, et al.
  • Organizer: Meeting of Asian Society of Oral and Maxillofacial Pathology (5th) / Annual meeting of the Japanese society of oral pathology (22th)
  • Place of Presentation: 九州大学医学部（福岡市）
• [Presentation] 歯科矯正学的メカニカルストレスによるマウス歯根膜組織におけるOsterixの発現 (2011)
  • Author(s): 松田浩和，他
  • Organizer: 歯科基礎医学会総会（第53回）
  • Place of Presentation: 長良川国際会議場（岐阜市）
• [Presentation] Orthodontic stress as a possible promoter of transplanted bone marrow-derived cell migration into periodontal tissues (2011)
  • Author(s): Muraoka R, et al.
  • Organizer: SIDO International Congress, Follow-up in Orthodontics (XXIII)
  • Place of Presentation: ローマカバリエリ（ローマ）
• [Presentation] 下顎臼歯根尖部病変
  • Author(s): 落合隆永，嶋田勝光，中野敬介，長谷川博雅
  • Organizer: 骨軟部腫瘍研究会（第49回）
  • Place of Presentation: 大分大学，大分市
• [Presentation] Calcifying epithelial odontogenic tumorにおけるNotchシグナルの検討
  • Author(s): 中野敬介，長塚 仁，落合隆永，長谷川博雅，川上敏行
  • Organizer: 日本病理学会総会（第102回）
  • Place of Presentation: ロイトン札幌，札幌市
• [Presentation] エナメル上皮腫における神経内分泌マーカーの発現
  • Author(s): 落合隆永，中野敬介，長谷川博雅
  • Organizer: 日本病理学会総会（第102回）
  • Place of Presentation: ロイトン札幌，札幌市
• [Presentation] Effect of HSP70 in the periodontal ligaments remodeling due to orthodontic force
  • Author(s): Muraoka R, Nakano K, Yamada K and Kawakami T
  • Organizer: 89th Congress of the European Orthodontic Society
  • Place of Presentation: Reykjavik, Iceland
• [Presentation] Cell dynamism of the periodontal tissues remodeling elicited by orthodontic mechanical stress
  • Author(s): Kawakami T, Nakano K, Tomida M, Muraoka R and Yamada K
  • Organizer: 89th Congress of the European Orthodontic Society
  • Place of Presentation: Reykjavik, Iceland
• [Presentation] Cytological remodeling of the periodontal ligament tissues due to mechanical stress
  • Author(s): Kawakami T, Tomida M, Muraoka R, Nakamura T and Nakano K
  • Organizer: The 37th International Congress of Physiological Sciences
  • Place of Presentation: Birmingham, UK
• [Presentation] 外傷ストレスを負荷した歯周組織変化
  • Author(s): 岡藤範正，中野敬介，魚住智子，山木貴子，安東信行，安東史子，中村曲正，横井由紀子，大須賀直人，西川康弘
  • Organizer: 日本外傷歯学会総会・学術大会 (第13回)
  • Place of Presentation: 所沢市民文化センターミューズ，所沢市
• [Presentation] 歯科矯正学的メカニカルストレスによりマウス歯根膜に発現する HSP47 の分子シャペロンとしての可能性
  • Author(s): 村岡理奈，山田一尋，中野敬介，川上敏行
  • Organizer: 硬組織再生生物学会（第22回）
  • Place of Presentation: 鶴見大学歯学部，横浜市
• [Presentation] 歯科矯正学的メカニカルストレスによる歯周組織改造時における細胞動態
  • Author(s): 宮城圭子，富田美穂子，中野敬介，村岡理奈，中村貴美，岡藤範正，川上敏行
  • Organizer: 硬組織再生生物学会（第22回）
  • Place of Presentation: 鶴見大学歯学部，横浜市
• [Presentation] マウスにおける実験的慢性根尖炎症性病巣の確立
  • Author(s): 松田紗衣佳，正村正仁，森山敬太，大須賀直人，中野敬介，川上敏行
  • Organizer: 日本臨床口腔病理学会総会（第24回）
  • Place of Presentation: 日本大学理工学部，東京
• [Presentation] 骨治癒過程における骨髄由来細胞の関与
  • Author(s): 河合穂高，辻極秀次，伊藤 聡，中野敬介，于 淞，川上敏行，長塚 仁
  • Organizer: 歯科基礎医学会総会（第55回）
  • Place of Presentation: 岡山大学，岡山市
• [Presentation] 歯科的矯正学的メカニカルストレスが惹起するHSP27のマウス歯根膜細胞における局在変化
  • Author(s): 村岡理奈，中野敬介，山田一尋，川上敏行
  • Organizer: 歯科基礎医学会総会（第55回）
  • Place of Presentation: 岡山大学，岡山市
• [Presentation] マウス歯根膜細胞に発現するHSP47の分子シャペロンとしての可能性
  • Author(s): 村岡理奈，中野敬介，松田浩和，川上敏行，岡藤範正，山田一尋
  • Organizer: 日本矯正歯科学会大会（第72回）
  • Place of Presentation: 長野県松本文化会館，松本市
• [Presentation] Migration and differentiation of transplanted bone marrow-derived cells into periodontal tissues promoted by mechanical stress
  • Author(s): Kawakami T
  • Organizer: Congress of the European Hematology Association (17th)
  • Place of Presentation: Amsterdam, Holland
• [Presentation] Migration of the transplanted bone marrow-derived cells into periodontal ligaments due to orthodontic mechanical stress
  • Author(s): Tomida M
  • Organizer: Physiology 2012
  • Place of Presentation: Edinburgh, UK
• [Presentation] メカニカルストレスが骨髄由来細胞の歯周組織への移動に及ぼす影響
  • Author(s): 富田美穂子
  • Organizer: 歯科基礎医学会総会（第54回）
  • Place of Presentation: 奥羽大学，郡山市
• [Presentation] マウスの歯科矯正学的牽引側歯周組織に発現するOsterixの蛍光免疫染色による検討
  • Author(s): 松田浩和
  • Organizer: 日本矯正歯科学会大会（第71回）
  • Place of Presentation: 盛岡市民文化ホール，盛岡市
• [Book] Kawakami T ed : Pathological Basis of Root Canal Restoration -Using Calcium Hydroxide Paste- (ISBN-10: 4905130069, ISBN-13: 978-4905130062) (2012)
  • Author(s): Antoh M, Fuchino T, Fujii H, Hasegawa H, Kawakami T, Machida Y, Mizutani T, NakamuraC, Nakano K, Ochiai T, Sato M, Shibuya T, Takei N, Teramoto S, Tomida M, Yumii T
  • Publisher: IDP Publishing Inc,Tokyo,Japan
• [Book] Chapter 5: Histopatholo- gical and immunohistochemical background of orthodontic treatment. In Berhardt LV ed : Advances in Medicine and Biology Volume 18 (2011)
  • Author(s): Kawakami T, Nakano K, Shimizu T, Kimura A, Okafuji N, Tsujigiwa H, Hasegawa H and Nagatsuka H
  • Publisher: Nova Science Publishers, New York, USA
• [Book] Advances in Medicine and Biology Volume 18 (2011)
  • Author(s): Kawakami T, Nakano K, et al.
  • Total Pages: 346
  • Publisher: Nova Science Publishers