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The effect of EGF receptor pathway on cytokine production in gingival fibroblasts

Research Project

Project/Area Number 23593077
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionHimeji Dokkyo University

Principal Investigator

KOGOE Nahoko  姫路獨協大学, 薬学部, 助手 (60509115)

Co-Investigator(Kenkyū-buntansha) OHYAMA Hideki  兵庫医科大学, 医学部, 准教授 (90280685)
KURODA Yoshihiro  姫路獨協大学, 薬学部, 教授 (90093236)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsEGFR / 歯肉線維芽細胞 / 歯肉上皮細胞 / CCL17 / CCL22 / 歯周病 / BAFF / APRIL
Research Abstract

This study focused on the effects of EGF-R pathway on the productivity of chemokines and cytokines in gingival fibroblasts and gingival epithelial cells. We found that inhibition of EGF-R signaling leads to the expression of BAFF, APRIL, and TSLP that is cytokines help to shape the local accumulation and activation of Th2 responses and B cell immunoglobulin production. In addition, EGF-R signaling blockade produces the effect with increased Th2 chemokines, CCL11, CCL17, and CCL26 expression, although no effect with Th1 chemokines, CXCL9, CXCL10, and CXCL11 expression in gingival fibroblasts. These results may imply additional mechanisms by which EGF-R pathway the immune responses in periodontal lesion.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results)

  • [Journal Article] Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells.2013

    • Author(s)
      Kuroda Y, Kato-Kogoe N, Tasaki E, Murata M, Ueda K, Abe M, Miyamoto K, Nakase I, Futaki S, Tohyama Y, Hirose M
    • Journal Title

      Eur J Pharmacol

      Volume: 698 Issue: 1-3 Pages: 87-94

    • DOI

      10.1016/j.ejphar.2012.10.007

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] T-cell Responses Involved in the Predisposition to Periodontal Disease: Lessons from Immunogenetic Studies of Leprosy2013

    • Author(s)
      Hideki Ohyama, Nahoko Kato-Kogoe, Kazu Takeuchi-Hatanaka, Koji Yamanegi, Naoko Yamada, Keiji Nakasho, Sho Matsushita and Nobuyuki Terada
    • Journal Title

      J Clin Cell Immunol

      Volume: S1 Pages: 1-7

    • DOI

      10.4172/2155-9899.s1-005

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The promotional effect of IL-22 on mineralization activity of periodontal ligament cells2012

    • Author(s)
      Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H
    • Journal Title

      Cytokine

      Volume: 59(1) Issue: 1 Pages: 41-8

    • DOI

      10.1016/j.cyto.2012.03.024

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of TrkA inhibitory peptide on cancer-induced pain in a mouse melanoma model.2012

    • Author(s)
      Tabata M, Murata E, Ueda K, Kato-Kogoe N, Kuroda Y, Hirose M
    • Journal Title

      J Anesth

      Volume: 26 Issue: 4 Pages: 545-551

    • DOI

      10.1007/s00540-012-1377-7

    • NAID

      10031070301

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma2012

    • Author(s)
      Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, YamadaN, Hata M, Fukunaga S, Futani H, Okamura H, Terada N.
    • Journal Title

      cells to Fas- and NK cell-mediated cell death.Int J Oncol.

      Volume: 41(1) Pages: 83-91

    • DOI

      10.3892/ijo.2012.1438

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The promotional effect of IL-22 on mineralization activity of periodontal ligament cells.2012

    • Author(s)
      Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H.
    • Journal Title

      Cytokine.

      Volume: Apr 24

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death.2012

    • Author(s)
      Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N.
    • Journal Title

      Int J Oncol.

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of TrkA inhibitory peptide on cancer-induced pain in a mouse melanoma model.2012

    • Author(s)
      Tabata M, Murata E, Ueda K, Kato-Kogoe N, Kuroda Y, Hirose M.
    • Journal Title

      J Anesth.

      Volume: in press

    • NAID

      10031070301

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] IGF-1Rの自己リン酸化部位由来ペプチドがMCF-7ヒト乳がん細胞に及ぼす影響2013

    • Author(s)
      黒田義弘,小越菜保子,田崎絵美,中瀬生彦,二木史朗,通山由美,廣瀬宗孝
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] EGFRの自己リン酸化部位由来ペプチドのA549ヒト肺腺がん細胞における効果2011

    • Author(s)
      黒田義弘,村田恵理,上田康陽,田崎絵美,小越菜保子,阿部峰大,宮本和英,中瀬生彦,二木史朗,通山由美,廣瀬宗孝
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] IL‐22存在下においてヒト歯根膜由来細胞が発現する遺伝子の網羅的解析2011

    • Author(s)
      川辺睦記,大山秀樹,安川陽子,小越菜保子,安孫子宜光
    • Organizer
      第54回日本歯周病学会春季学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2011-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] EGFRの自己リン酸化部位由来ペプチドの A549ヒト肺腺がん細胞における効果2011

    • Author(s)
      黒田義弘,村田恵理,上田康陽,田崎絵美,小越菜保子,阿部峰大,宮本和英,中瀬生彦,二木史朗,通山由美,廣瀬宗孝
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] IL-22がヒト歯根膜由来細胞の石灰化ノジュール形成に及ぼす影響2011

    • Author(s)
      大山 秀樹,小越 菜保子,川辺 睦記,安川 陽子,安孫子 宜光
    • Organizer
      第54回春季日本歯周病学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] IL-22存在下においてヒト歯根膜由来細胞が発現する遺伝子の網羅的解析2011

    • Author(s)
      川辺睦記,大山秀樹,安川陽子,小越菜保子,安孫子宜光
    • Organizer
      第54回春季日本歯周病学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] IGF-1Rの自己リン酸化部位由来ペプチドがMCF-7ヒト乳がん細胞に及ぼす影響

    • Author(s)
      黒田 義弘
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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