| Project/Area Number |
23593077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
KOGOE Nahoko 姫路獨協大学, 薬学部, 助手 (60509115)
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| Co-Investigator(Kenkyū-buntansha) |
OHYAMA Hideki 兵庫医科大学, 医学部, 准教授 (90280685)
KURODA Yoshihiro 姫路獨協大学, 薬学部, 教授 (90093236)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | EGFR / 歯肉線維芽細胞 / 歯肉上皮細胞 / CCL17 / CCL22 / 歯周病 / ＢＡＦＦ / ＡＰＲＩＬ |
|---|
| Research Abstract |
This study focused on the effects of EGF-R pathway on the productivity of chemokines and cytokines in gingival fibroblasts and gingival epithelial cells. We found that inhibition of EGF-R signaling leads to the expression of BAFF, APRIL, and TSLP that is cytokines help to shape the local accumulation and activation of Th2 responses and B cell immunoglobulin production. In addition, EGF-R signaling blockade produces the effect with increased Th2 chemokines, CCL11, CCL17, and CCL26 expression, although no effect with Th1 chemokines, CXCL9, CXCL10, and CXCL11 expression in gingival fibroblasts. These results may imply additional mechanisms by which EGF-R pathway the immune responses in periodontal lesion.
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