Implications of CYP2A6 genetic variation for smoking behaviors and periodontal disease
| Project/Area Number |
23593079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University,Junior College |
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Principal Investigator |
INAGAKI KOJI 愛知学院大学短期大学部, 歯科衛生学科, 教授 (50211058)
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| Co-Investigator(Kenkyū-buntansha) |
KAMEI Hidehiko 愛知学院大学, 歯学部, 講師 (50421243)
MORITA Ichizo 愛知学院大学, 歯学部, 講師 (50301635)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 喫煙 / 社会的ニコチン依存度 / 歯周病 / ニコチン代謝能 / 受動喫煙 / 遺伝子多型 / CYP2A6 / ニコチン / 歯周炎 / コチニン |
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| Research Abstract |
The sample comprised 89% non-smokers, 3% ex-smokers, and 8% smokers. Also, 35% of students responded that they inhaled secondhand smoke at home. Thirty-seven percent of students had signs of gingival bleeding, while 21% had signs of swelling. The frequency of interdental device use was 29%. Also, 30% of all smoking students thought that a price of 500 yen for cigarettes would deter smoking, while 68% of students said they disliked students who smoked. The Kano Test for Social Nicotine Dependence (KTSND) scores in smokers were higher than those of non-smokers and ex-smokers. In addition, male students demonstrated higher KTSND scores than did female students. KTSND scores for non-smoking students exposed to secondhand smoke were higher than those not exposed to secondhand smoke. We did not find any relationship between CYP2A6 genetic polymorphisms and periodontal conditions among chronic periodontitis patients with smoking.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease2013
Author(s)
Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Fukui M, Nakamura N, Oseko F, Kanamura N, Inagaki K, Noguchi T, Naruse K, Matsubara T, Miyazaki S, Miyauchi T, Ando Y, Hanada N, Inoue S.
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Journal Title
J Diabetes Invest
Volume: 4(3)
Pages: 320-325
Related Report
Peer Reviewed
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[Journal Article] Salivary biomarkers for predicting the progression of chronic periodontitis2012
Author(s)
Nomura Y, Shimada Y, Hanada N, Numabe Y, Kamoi K, Sato T, Gomi K, Arai T, Inagaki K, Fukuda M, Noguchi T, Yoshie H
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Journal Title
Arch Oral Biol
Volume: 57
Pages: 413-420
Related Report
Peer Reviewed
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[Journal Article] Smoking status and the Kano test for social nicotine dependence (KTSND) in hospital employees in a regional cancer center in Japan2012
Author(s)
Amagai K, Nakamura Y, Yoshii C, Kano M, Inagaki K, Kitada M, Otani T, Harada S, Kurioka N, Tanaka M, Tanaka H
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Journal Title
Jpn J Tob Control
Volume: 6
Pages: 71-84
Related Report
Peer Reviewed
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[Presentation] Smoking status and social nicotine dependence among Japanese dental and pharmacy undergraduates2011
Author(s)
Inagaki K, Kosaka T, Mukai M, Noguchi T, Morita I, Nakagaki H, Didilescu AC, Otani T, Yoshii C, Kano M
Organizer
The 37th Annual Meeting of Association for Dental Education in Europe
Place of Presentation
Antalya, Turkey
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[Presentation] Smoking-related cognition, secondhand smoke exposure, the awareness of smoking and the effects of anti-smoking education for fifth and sixth grade elementary school children
Author(s)
Inagaki K, Kamei H, Noguchi T, Morita I, Ieda S, Isomura T, Uozumi K, Ohsawa I, Taniguchi C, Yamaguchi Y, Kitada M, Endo A, Yoshii C, Kano M.
Organizer
The 10th Meeting of Asia Pacific Conference on Tobacco or Health 2013
Place of Presentation
幕張メッセ (千葉市美浜区)
Related Report
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