| Project/Area Number |
23593082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KASAHARA Eriko 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (50597325)
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| Co-Investigator(Kenkyū-buntansha) |
SHOJI Noriaki 東北大学, 病院, 講師 (70250800)
SASANO Takashi 東北大学, 歯学研究科(研究院), 教授 (10125560)
ICHIKAWA Hiroyuki 東北大学, 歯学研究科(研究院), 教授 (20193435)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | CRH / 急性痛 / 慢性痛 / ストレス / c-fos |
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| Research Abstract |
Recently, patients having chronic pain in the maxillofacial region, atypical odontalgia and glossodynia are increasing, and this becomes a social problem. However, it is not clear the mechanism of chronic pain and method of treatment. The aim of this study is diagnosis of stress of pain and correct therapy. We considered that the pain is one of impression as stressor, and analyzed the influence of the stress on the hypothalamus-pituitary-adrenal(HPA) axis and paraventricular hypothalamic nucleus(PVN). In this study, we inject the solution of capsaicin at the tip of the rat tongue that is controlled by the mandibular nerve branched from the trigeminal nerve, and clear the change in PVN by acute pain stress and following nerve injury.It is provided that the c-fos gene transcription which is a neuronal exciting marker is increasing in both the hypothalamic PVN and the trigeminal ganglion.
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