| Project/Area Number |
23593083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TANDA Naoko 東北大学, 大学病院, 助教 (00422121)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHIKAWA Yasushi 東北大学, 加齢医学研究所, 助教 (90333814)
TAKAHSI Nobuhiro 東北大学, 歯学研究科(研究院), 教授 (60183852)
KOSEKI Takeyoshi 東北大学, 歯学研究科(研究院), 教授 (80291128)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 周術期 / 肺癌 / 誤嚥性肺炎 / 呼気 / 口腔ケア / 口腔内細菌 / 口内気体 / 上気道反射 / 口臭 / 口腔細菌叢 / 肺がん / 呼気分析 / 周術期口腔ケア |
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| Research Abstract |
We analyzed gasses from exhaled and mouth air and saliva of perioperative patients of lung cancer at bedside before oral care, after oral care before operation, and after operation. Protective reflexes (cough and swallowing reflex) were also measured before and after operation. As for patients without postoperative pneumonia, oral care before operation increased ratio of salivary streptococci, usually known as healthy-associated bacteria, in anaerobic condition. Oral care also decreased total number of bacteria in saliva and decreased malodorous gasses. Acetone concentration increased after operation with rapid increase of CRP.
This study suggests possibility that non-invasive measuring volatile sulfide compounds and volatile organic compounds at bedside indicate oral environments and general inflammatory conditions of perioperative lung cancer.
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