Development of evaluation system for systemic infectious disease by oral bacteria based on the adherence to host tissues
| Project/Area Number |
23593093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
YAMAGUCHI TAIHEI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (80230358)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Yasushi 鹿児島大学, 農学研究科, 教授 (10100736)
OHO Takahiko 鹿児島大学, 医歯学総合研究科, 教授 (50160940)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 口腔細菌 / 感染 / 初期付着 / 付着因子 / 細胞外基質 / フィブロネクチン / トランスフェリン / アミラーゼ |
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| Research Abstract |
Streptococcus intermedius adhered to salivary agglutinin. Concentration of salivary agglutinin varied among individuals considerably. Novel fibronectin-binding proteins derived from Granulicatella adiacens and Granulicatella para-adiacens were identified. The adherence was inhibited by serum transferrin in the dose dependent manner of Fe3+ ion. Fusobacterium nucleatum adhered to salivary amylase, and more bacterial cells adhered to dimer-molecule of amylase than to monomer-molecule.
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Report
(4 results)
Research Products
(18 results)
