Mechanism of Micromolar NaF in anti-osteoclastogenesis
| Project/Area Number |
23593110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
ARAKAWA Hirohisa 神奈川歯科大学, 歯学研究科(研究院), 教授 (00130906)
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| Co-Investigator(Kenkyū-buntansha) |
BHAWAL Ujjal 日本大学, 松戸歯学部, 助教 (50433339)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 低濃度フッ化物 / 骨芽細胞 / 破骨細胞 / 実験的歯周病モデル / 炎症状態 / 破骨細胞分化 / 抗菌活性 |
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| Research Abstract |
We report here that Sprague-Dawley rat tissue samples of P. gingivalis ATCC 33277 group with bone resorption visible on micro computed tomography, exhibited a marked increase in cathepsin K, NFATc1, MMP9, and IL-1beta expression compared with those of P. gingivalis + NaF group. Specimens were also confirmed by staining with tartrate-resistant acid phosphatase and by measuring the distance between the cemento-enamel junction and the alveolar bone crest. Moreover, bone marrow cells formed osteoclasts in vitro with exogenous receptor activator of RANKL or M-CSF and micromolar NaF inhibited osteoclast formation. Additionally, cultured bone marrow cells of NaF group expressed higher levels of osteoprotegerin than did control group. These results suggest a model for understanding the pathogenesis of aggressive bone loss in periodontitis and anti-osteoclastogenesis function of micromolar NaF.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Silk fibroin-based scaffolds for bone regeneration2013
Author(s)
Kuboyama N, Kiba H, Arai K, Uchida R, Tanimoto Y, Bhawal UK, Abiko Y, Miyamoto S, Knight D, Asakura T, Nishiyama N.
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: Vol.101
Issue: 2
Pages: 295-302
DOI
Related Report
Peer Reviewed
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[Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell,and in mouse liver2012
Author(s)
Sato F, Sato H, Jin D, Bhawal UK, Wu Y, Noshiro M,Kawamoto T, Fujimoto K,Seino H, Morohashi S,Kato Y,Kijima H.
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Journal Title
Biochemical Biophysics Research Communication
Volume: 419(2)
Pages: 441-446
Related Report
Peer Reviewed
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[Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingival inflammation2012
Author(s)
Ito Y, Bhawal UK, Sasahira T, Toyama T, Sato T,Matsuda D, Nishikiori H, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H.
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Journal Title
Archives of Oral Biology
Volume: 57(1)
Pages: 73-80
Related Report
Peer Reviewed
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[Journal Article] Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D12011
Author(s)
Bhawal UK, Sato F, Arakawa Y, Fujimoto K,Kawamoto T, Tanimoto K, Ito Y, Sasahira T,Sakurai T, Kobayashi M, Kashima I, Kijima H,Kuniyasu H, Abiko Y, Kato Y, Sato S.
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Journal Title
Journal of Pathology
Volume: 224(3)
Pages: 420-429
Related Report
Peer Reviewed
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