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Intervention Study of Sialogogic Effects for the Prevention of Chemotherapy-Associated Stomatitis

Research Project

Project/Area Number 23593210
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fundamental nursing
Research InstitutionFukuoka University

Principal Investigator

YOSHIKAWA Chizuko  福岡大学, 医学部, 准教授 (60461539)

Co-Investigator(Kenkyū-buntansha) OGATA Kentaro  福岡大学, 薬学部, 講師 (60509636)
HARADA Hiroe  国際医療福祉大学, 保健医療学部, 教授 (60380383)
NAKASHIMA Emiko  福岡大学, 医学部, 教授 (30461536)
SUZAKI Shinobu  福岡大学, 医学部, 助手 (20469381)
YAMASHITA Chinami  福岡大学, 医学部, 助手 (30469382)
KAWAGUCHI Kazuko  国際医療福祉大学, 保健医療学部, 准教授 (40469383)
Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsがん化学療法 / 口内炎予防 / 唾液分泌促進 / 介入研究 / 介入
Outline of Final Research Achievements

This study was to develop an oral care program that uses the power of saliva for the prevention of stomatitis associated with cancer chemotherapy. In Phase 1, we provided intervention to perform cevimeline hydrochloride hydrate gargling (CHH gargling). In Phase 2, patient self-assessments regarding the oral environment were compared with the assessments of others. In Phase 3, oral mucosal damage was investigated. In Phase 4, the effect of functional oral care on saliva components was examined. In Phase 5, we provided oral care intervention based on the results obtained in the first four phases. The results revealed the necessity of an oral care program comprising the following essential elements: (1) assessment of oral mucosal damage risk by therapy regimen, (2) professional oral health care according to assessed risk, (3) appropriate assessment of the oral environment, (4) oral care that promotes saliva secretion and enhances the self-cleansing function, and (5) self-care guidance

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] セビメリン含嗽液の唾液分泌促進作用に関する研究2013

    • Author(s)
      吉川千鶴子、高松 泰、緒方憲太郎、原 周司、田村和夫
    • Journal Title

      癌と化学療法

      Volume: 40(2) Pages: 215-219

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] がん化学療法を受ける患者の看護師による口腔ケア介入の有用性2016

    • Author(s)
      吉川千鶴子
    • Organizer
      第30回日本がん看護学会学術集会
    • Place of Presentation
      千葉県 幕張メッセ
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機能的口腔ケア(口腔体操・唾液腺マッサージ)による刺激と唾液分泌の基礎的研究2015

    • Author(s)
      吉川千鶴子
    • Organizer
      第12回日本口腔ケア学会学術大会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2015-06-27 – 2015-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] がん化学療法における口腔粘膜障害の後方視的検討~悪性リンパ腫、白血病、消化器がんの比較~2014

    • Author(s)
      吉川千鶴子
    • Organizer
      日本がん看護学会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] がん化学療法における口腔アセスメントの自己評価と他者評価の比較2013

    • Author(s)
      吉川千鶴子
    • Organizer
      日本がん看護学会
    • Place of Presentation
      石川県立音楽堂
    • Related Report
      2012 Research-status Report
  • [Presentation] Prevention of Chemotherapy-Associated Stomatitis by Rinsing and Gargling with Cevimeline Hydrochloride Hydrate Solution2012

    • Author(s)
      Chizuko Yoshikawa
    • Organizer
      International Research Consortium 19th International Conference
    • Place of Presentation
      College of Nursing Keimung University Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] がん化学療法時の口内炎に対する塩酸セビメリン含嗽の臨床的検討2012

    • Author(s)
      吉川千鶴子
    • Organizer
      第26回日本がん看護学会
    • Place of Presentation
      島根県松江市
    • Related Report
      2011 Research-status Report
  • [Book] がんナーシングVol.3no.22013

    • Author(s)
      吉川千鶴子
    • Publisher
      メディカ出版
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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