Influence of Illumination During Mydriasis for Fundus Examination on Stress Response in Premature Infants : Analysis of Saliva, Behavior, and Heart Rate Variability

Research Project

Project/Area Number	23593344
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Lifelong developmental nursing
Research Institution	International University of Health and Welfare
Principal Investigator	HORIGANE Yukie 国際医療福祉大学, 保健医療学部, 講師 (90588857)
Co-Investigator(Kenkyū-buntansha)	高橋眞理 (高橋真理) 北里大学, 看護学部 (20216758)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000) Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords	早産児 / 光環境 / ストレス / 唾液クロモグラニンA / 自律神経活動 / 早産児行動評価 / 光 / 唾液分析 / 自律神経 / 行動評価 / 自律神経活動評価 / コルチゾール / 心拍変動解析
Research Abstract	Objective:This study aimed to evaluate the influence of low and normal illumination during fundus examination on the stress response in premature infants through the evaluation of saliva, behavior, and autonomic nervous activity reflected by heart rate variability.Methods: A total of 36 premature infants who were born at an average gestational age of 29.4 weeks (25.2 weeks-34.6 weeks) with an average birth weight of 1,296 g (727-2,146 g) were included in this study. All infants underwent fundus examination with the induction of mydriasis under normal illumination(control group) or low illumination (intervention group), and salivary chromogranin A levels, behavior, and heart rate variability were analyzed before and until 6 hours after the induction of mydriasis.Results: The mean salivary chromogranin A levels were significantly lower(40.51 +- 40.796 pmol/mg) in the intervention group than in the control group in (167.72 +- 84.634pmol/mg ; p < .05; t-test).